Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …

Pluripotency manifests during mammalian development through formation of the epiblast,
founder tissue of the embryo proper. Rodent pluripotent stem cells can be considered as two …

Pluripotent stem cells have the capacity to self renew and to differentiate to cells of the three
somatic germ layers that comprise an organism. Embryonic stem cells are the most studied …

Human naïve pluripotent stem cells (PSCs) share features with the pre-implantation epiblast.
They therefore provide an unmatched opportunity for characterising the developmental …

Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and
can be preserved in vitro in a naive inner-cell-mass-like configuration by providing …

Human pluripotent stem cells from embryonic origins and those generated from
reprogrammed somatic cells share many characteristics, including indefinite proliferation …

Mouse embryonic stem (ES) cells are pluripotent, as they have the ability to differentiate into
the various cell types of a vertebrate embryo. Pluripotency is a property of the inner cell …

The inner cell mass of pre-implantation blastocyst stage embryos is a source of cells that can
be cultured indefinitely in vitro as a self-renewing, pluripotent population. In this review, we …

Human embryonic stem cells (hESCs) closely resemble mouse epiblast stem cells exhibiting
primed pluripotency unlike mouse ESCs (mESCs), which acquire a naïve pluripotent state …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …