Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

The molecular events that lead to the cancer-initiating cell involve critical mutations in genes
regulating normal cell growth and differentiation. Cancer stem cells, or cancer initiating cells …

We propose that deregulation of proliferation, together with a reduction in apoptosis, creates
a platform that is both necessary and can be sufficient for cancer. The secondary traits of …

During the course of tumor progression, cancer cells acquire a number of characteristic
alterations. These include the capacities to proliferate independently of exogenous growth …

Cancer cell heterogeneity is a universal feature of human tumors and represents a
significant barrier to the efficacy and duration of anticancer therapies, especially targeted …

The cancer stem cell hypothesis is an evolving concept of oncogenesis that has recently
gained wide acceptance. In its simplest form this hypothesis suggests that many if not all …

Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

Solid tumors arise in organs that contain stem cell populations. The tumors in these tissues
consist of heterogeneous populations of cancer cells that differ markedly in their ability to …

Metastasis is a major obstacle to the efficient and successful treatment of cancer. Initiation of
metastasis requires epithelial‐mesenchymal transition (EMT) that is regulated by several …

Identification of the cell types capable of initiating and sustaining growth of the neoplastic
clone in vivo is a fundamental problem in cancer research. It is likely that tumor growth can …