Perfusion of isolated rat kidney with Mesenchymal Stromal Cells/Extracellular Vesicles prevents ischaemic injury

M Gregorini, V Corradetti, EF Pattonieri… - Journal of Cellular …, 2017 - Wiley Online Library
Kidney donation after circulatory death (DCD) is a less than ideal option to meet organ
shortages. Hypothermic machine perfusion (HMP) with Belzer solution (BS) improves the …

[HTML][HTML] Extracellular vesicles derived from mesenchymal stromal cells delivered during hypothermic oxygenated machine perfusion repair ischemic/reperfusion …

T Rampino, M Gregorini, G Germinario, EF Pattonieri… - Biology, 2022 - mdpi.com
Simple Summary In this study, we explore for the first time an innovative tool for organ
preservation aimed to preventing ischemia reperfusion injury (IRI) in marginal kidneys from …

[HTML][HTML] Human mesenchymal stromal cell-derived extracellular vesicles alleviate renal ischemic reperfusion injury and enhance angiogenesis in rats

X Zou, D Gu, X Xing, Z Cheng, D Gong… - American journal of …, 2016 - ncbi.nlm.nih.gov
Background: Mesenchymal stromal cells (MSCs) derived extracellular vesicles (EVs) were
regarded as a potent medium for kidney injury repair and angiogenesis were regarded as …

Adipose-derived mesenchymal stromal cells under hypoxia: changes in extracellular vesicles secretion and improvement of renal recovery after ischemic injury

F Collino, JA Lopes, SC Corrêa, ESFW Abdelhay… - 2019 - ninho.inca.gov.br
Background/Aims: The therapeutic potential of extracellular vesicles (EVs) derived from
mesenchymal stromal cells (MSCs) in kidney injury has been largely reported. However …

Potentiating renal regeneration using mesenchymal stem cells

L Brasile, N Henry, G Orlando, B Stubenitsky - Transplantation, 2019 - journals.lww.com
Background The potential of a mesenchymal stem cell (MSC) therapy to accelerate the
repair of ischemically damaged human kidneys during 24 hours of warm perfusion was …

[HTML][HTML] Reparative effect of mesenchymal stromal cells on endothelial cells after hypoxic and inflammatory injury

JM Sierra-Parraga, A Merino, M Eijken… - Stem cell research & …, 2020 - Springer
Background The renal endothelium is a prime target for ischemia-reperfusion injury (IRI)
during donation and transplantation procedures. Mesenchymal stromal cells (MSC) have …

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia–reperfusion-induced acute and chronic kidney injury

S Gatti, S Bruno, MC Deregibus, A Sordi… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. Several studies demonstrated that mesenchymal stem cells (MSCs) reverse
acute kidney injury (AKI) by a paracrine mechanism rather than by MSC transdifferentiation …

Renal regenerative potential of different extracellular vesicle populations derived from bone marrow mesenchymal stromal cells

S Bruno, M Tapparo, F Collino, G Chiabotto… - … Engineering Part A, 2017 - liebertpub.com
Extracellular vesicles (EVs) derived from human bone marrow mesenchymal stromal cells
(MSCs) promote the regeneration of kidneys in different animal models of acute kidney …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges

A Aghajani Nargesi, LO Lerman, A Eirin - Stem cell research & therapy, 2017 - Springer
Novel therapies are urgently needed to address the rising incidence and prevalence of
acute kidney injury (AKI) and chronic kidney disease (CKD). Mesenchymal stem/stromal …

[HTML][HTML] Administration of mesenchymal stromal cells before renal ischemia/reperfusion attenuates kidney injury and may modulate renal lipid metabolism in rats

P Erpicum, P Rowart, L Poma, JM Krzesinski… - Scientific Reports, 2017 - nature.com
Mesenchymal stromal cells (MSC) have been demonstrated to attenuate renal
ischemia/reperfusion (I/R) damage in rodent models. The mechanisms of such nephro …