Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy
For many years, delivering drug molecules across the blood brain barrier has been a major
challenge. The neuropeptide nerve growth factor is involved in the regulation of growth and …
challenge. The neuropeptide nerve growth factor is involved in the regulation of growth and …
[HTML][HTML] Targeted delivery of fat extract by platelet membrane-cloaked nanocarriers for the treatment of ischemic stroke
C Wang, X Yang, Y Jiang, L Qi, D Zhuge, T Xu… - Journal of …, 2022 - Springer
Background Our previous studies suggest that human fat extract (FE) contains a variety of
angiogenic factors and may provide an alternative treatment option for stroke. However, the …
angiogenic factors and may provide an alternative treatment option for stroke. However, the …
Preparation and characterization of biocompatible chitosan nanoparticles for targeted brain delivery of peptides
Here, we describe a nanocarrier system that can transfer chitosan nanoparticles loaded with
either small peptides such as the caspase inhibitor Z-DEVD-FMK or a large peptide like …
either small peptides such as the caspase inhibitor Z-DEVD-FMK or a large peptide like …
[HTML][HTML] Hyaluronate nanoparticles as a delivery system to carry neuroglobin to the brain after stroke
S Blanco, S Peralta, ME Morales, E Martínez-Lara… - Pharmaceutics, 2020 - mdpi.com
Therapies against stroke can restore the blood supply but cannot prevent the ischemic
damage nor stimulate the recovery of the infarcted zone. The neuroglobin protein plays an …
damage nor stimulate the recovery of the infarcted zone. The neuroglobin protein plays an …
[HTML][HTML] New strategies for stroke therapy: nanoencapsulated neuroglobin
Stroke is a global health and socio-economic problem. However, no efficient preventive
and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen …
and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen …
Systemically administered brain-targeted nanoparticles transport peptides across the blood—brain barrier and provide neuroprotection
Although growth factors and anti-apoptotic peptides have been shown to be neuroprotective
in stroke models, translation of these experimental findings to clinic is hampered by limited …
in stroke models, translation of these experimental findings to clinic is hampered by limited …
[HTML][HTML] Microfluidic development of brain-derived neurotrophic factor loaded solid lipid nanoparticles: An in vitro evaluation in the post-traumatic brain injury …
F Sommonte, I Arduino, RM Iacobazzi, L Laera… - Journal of Drug Delivery …, 2024 - Elsevier
Microfluidic-based nanoscale drug delivery systems have risen to prominence in the field of
precision nanomedicine in recent years. This intriguing innovation could provide unique …
precision nanomedicine in recent years. This intriguing innovation could provide unique …
[HTML][HTML] Therapeutic effects of simultaneous delivery of nerve growth factor mRNA and protein via exosomes on cerebral ischemia
J Yang, S Wu, L Hou, D Zhu, S Yin, G Yang… - … Therapy-Nucleic Acids, 2020 - cell.com
Stroke is the leading neurological cause of death and disability all over the world, with few
effective drugs. Nerve growth factor (NGF) is well known for its multifaceted neuroprotective …
effective drugs. Nerve growth factor (NGF) is well known for its multifaceted neuroprotective …
Preparation and characterization of biocompatible chitosan nanoparticles for targeted brain delivery of peptides
Here, we describe a nanocarrier system that can transfer chitosan nanoparticles loaded with
either small peptides such as the caspase inhibitor Z-DEVD-FMK or a large peptide like …
either small peptides such as the caspase inhibitor Z-DEVD-FMK or a large peptide like …
Nanotechnological strategies for nerve growth factor delivery: Therapeutic implications in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
amyloid-β peptide misfolding and aggregation. Neurotrophic factors, such as nerve growth …
amyloid-β peptide misfolding and aggregation. Neurotrophic factors, such as nerve growth …