Objective: To review the pharmacology, pharmacokinetics, pharmacodynamics, efficacy
data, and adverse effects of spironolactone in the treatment of resistant hypertension. Data …

Objectives: This study sought to determine the current effectiveness and safety of
spironolactone for resistant hypertension. Methods: Pubmed, EMBASE and Cochrane …

Our objective was to estimate the effect of addition of low-dose spironolactone to previous
antihypertensive therapy in patients with resistant hypertension. Patients had 25 to 50 mg of …

The role of spironolactone in resistant hypertension management is unclear. The aim of this
prospective trial was to evaluate the antihypertensive effect of spironolactone in patients with …

Methods We have conducted an open observational study of the use of spironolactone 25–
50 mg in the management of patients with resistant hypertension. This drug was …

Objective The efficacy of add-on use of spironolactone in patients with resistant
hypertension has been investigated in several small studies. We performed this meta …

Background The treatment of resistant hypertension (RH) is challenging. Several
observational studies have suggested that the addition of spironolactone to triple-drug …

Background: We conducted a meta-analysis to summarize all available evidence from
randomized controlled trial studies regarding the clinical efficacy and safety of …

This study was designed to assess the effect of additional spironolactone on blood pressure
in patients with resistant hypertension. MEDLINE, EMBASE, and Cochrane Library were …

True resistant hypertension is relatively frequent, yet effective treatment is often difficult to
identify. In a new study, de Souza and colleagues demonstrate the potent blood pressure …