Effect of intravenous fluid treatment with a balanced solution vs 0.9% saline solution on mortality in critically ill patients: the BaSICS randomized clinical trial

FG Zampieri, FR Machado, RS Biondi, FGR Freitas… - Jama, 2021 - jamanetwork.com
Importance Intravenous fluids are used for almost all intensive care unit (ICU) patients.
Clinical and laboratory studies have questioned whether specific fluid types result in …

Effect of slower vs faster intravenous fluid bolus rates on mortality in critically ill patients: the basics randomized clinical trial

FG Zampieri, FR Machado, RS Biondi, FGR Freitas… - JAMA, 2021 - jamanetwork.com
Importance Slower intravenous fluid infusion rates could reduce the formation of tissue
edema and organ dysfunction in critically ill patients; however, there are no data to support …

Balanced crystalloids versus saline in critically ill adults—a systematic review with meta-analysis

NE Hammond, FG Zampieri, GL Di Tanna… - NEJM …, 2022 - evidence.nejm.org
Background The comparative efficacy and safety of balanced crystalloid solutions and saline
for fluid therapy in critically ill adults remain uncertain. Methods We systematically reviewed …

Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial

P Young, M Bailey, R Beasley, S Henderson, D Mackle… - Jama, 2015 - jamanetwork.com
Importance Saline (0.9% sodium chloride) is the most commonly administered intravenous
fluid; however, its use may be associated with acute kidney injury (AKI) and increased …

Association between type of fluid received prior to enrollment, type of admission, and effect of balanced crystalloid in critically ill adults: a secondary exploratory …

FG Zampieri, FR Machado, RS Biondi… - American Journal of …, 2022 - atsjournals.org
Rationale: The effects of balanced crystalloid versus saline on clinical outcomes for ICU
patients may be modified by the type of fluid that patients received for initial resuscitation …

[HTML][HTML] Balanced crystalloids versus saline in critically ill adults

MW Semler, WH Self, JP Wanderer… - … England Journal of …, 2018 - Mass Medical Soc
Background Both balanced crystalloids and saline are used for intravenous fluid
administration in critically ill adults, but it is not known which results in better clinical …

[PDF][PDF] Intravenous balanced solutions: from physiology to clinical evidence

T Langer, A Santini, E Scotti, N Regenmortel… - Anaesthesiology …, 2015 - termedia.pl
Abstract “Balanced” solutions are commonly defined as intravenous fluids having an
electrolyte composition close to that of plasma. As such, they should minimally affect acid …

[HTML][HTML] Resuscitation fluid types in sepsis, surgical, and trauma patients: a systematic review and sequential network meta-analyses

CH Tseng, TT Chen, MY Wu, MC Chan, MC Shih… - Critical Care, 2020 - Springer
Background Crystalloids and different component colloids, used for volume resuscitation,
are sometimes associated with various adverse effects. Clinical trial findings for such fluid …

[HTML][HTML] Intravenous fluid therapy in critically ill adults

S Finfer, J Myburgh, R Bellomo - Nature Reviews Nephrology, 2018 - nature.com
Intravenous fluid therapy is one of the most common interventions in acutely ill patients.
Each day, over 20% of patients in intensive care units (ICUs) receive intravenous fluid …

Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis

K Raghunathan, A Shaw, B Nathanson… - Critical care …, 2014 - journals.lww.com
Objective: Isotonic saline is the most commonly used crystalloid in the ICU, but recent
evidence suggests that balanced fluids like Lactated Ringer's solution may be preferable …