Disease-specific protein corona sensor arrays may have disease detection capacity

G Caracciolo, R Safavi-Sohi, R Malekzadeh… - Nanoscale …, 2019 - pubs.rsc.org
The earlier any catastrophic disease (eg, cancer) is diagnosed, the more likely it can be
treated, providing improved patient prognosis, extended survival and better quality of life. In …

A protein corona sensor array detects breast and prostate cancers

L Digiacomo, K Jafari-Khouzani, S Palchetti, D Pozzi… - Nanoscale, 2020 - pubs.rsc.org
Following exposure to human plasma (HP), nanoparticles (NPs) are coated with a
biomolecular layer referred to as a protein corona. We recently revealed that characterizing …

The human in vivo biomolecule corona onto PEGylated liposomes: a proof‐of‐concept clinical study

M Hadjidemetriou, S McAdam, G Garner… - Advanced …, 2019 - Wiley Online Library
The self‐assembled layered adsorption of proteins onto nanoparticle (NP) surfaces, once in
contact with biological fluids, is termed the “protein corona” and it is gradually seen as a …

Personalized protein corona on nanoparticles and its clinical implications

C Corbo, R Molinaro, M Tabatabaei… - Biomaterials …, 2017 - pubs.rsc.org
It is now well understood that once in contact with biological fluids, nanoscale objects lose
their original identity and acquire a new biological character, referred to as a protein corona …

Potential clinical applications of the personalized, disease-specific protein corona on nanoparticles

MG Vence, M del Pilar Chantada-Vazquez… - Clinica Chimica …, 2020 - Elsevier
Nanoscale objects lose their original identity once in contact with biological fluids and get a
new biological identity, referred to as a protein corona (PC). The PC modifies many of the …

Quantitative profiling of the protein coronas that form around nanoparticles

D Docter, U Distler, W Storck, J Kuharev, D Wünsch… - Nature protocols, 2014 - nature.com
Nanoparticle applications in biotechnology and biomedicine are steadily increasing. In
biological fluids, proteins bind to nanoparticles that form the protein corona, crucially …

No king without a crown–impact of the nanomaterial-protein corona on nanobiomedicine

D Docter, S Strieth, D Westmeier, O Hayden… - …, 2015 - Taylor & Francis
Besides the wide use of nanomaterials in technical products, their application spectrum in
biotechnology and biomedicine is steadily increasing. Whereas the physico-chemical …

Nanoparticle protein corona evolution: from biological impact to biomarker discovery

N Kamaly, OC Farokhzad, C Corbo - Nanoscale, 2022 - pubs.rsc.org
Nanoparticles exposed to biological fluids such as blood, quickly interact with their
surrounding milieu resulting in a biological coating that results in large part as a function of …

Analysing the nanoparticle-protein corona for potential molecular target identification

CK Elechalawar, MN Hossen, L McNally… - Journal of Controlled …, 2020 - Elsevier
When nanoparticles are introduced into biological systems, host proteins tend to associate
on the particle surface to form a protein layer termed the “protein corona”(PC). Identifying the …

An overview of nanoparticle protein corona literature

MJ Hajipour, R Safavi‐Sohi, S Sharifi, N Mahmoud… - Small, 2023 - Wiley Online Library
The protein corona forms spontaneously on nanoparticle surfaces when nanomaterials are
introduced into any biological system/fluid. Reliable characterization of the protein corona is …