Alterations in connexins and specifically in 43 isoform (Cx43) in the heart have been
associated with a high incidence of arrhythmogenesis and sudden death in several cardiac …

Abstract Unapposed connexin 43 hemichannels (Cx43Hc) are present on sarcolemma of
cardiomyocytes. Whereas Cx43Hc remain closed during physiological conditions, their …

Heart failure is known to predispose to life-threatening ventricular tachyarrhythmias even
before compromising the systemic circulation, but the underlying mechanism is not well …

Abstract Connexin-43 (Cx43), a predominant cardiac connexin, forms gap junctions (GJs)
that facilitate electrical cell–cell coupling and unapposed/nonjunctional hemichannels that …

The opening of unapposed connexin 43 hemichannels (Cx43Hc) under ischemic stress
leads to cell death and irreversible tissue injury. Here, we investigate for the first time in vivo …

Introduction: Heart failure is associated with reduced expression of the major gap junction
protein connexin43 (Cx43), which may contribute to arrhythmias and sudden cardiac death …

Intercellular channels of gap junctions are formed in vertebrates by the protein family of
connexins and allow direct exchange of ions, metabolites and second messenger molecules …

Aims We have shown that failing human and rabbit left ventricle (LV) exhibits
downregulation and dephosphorylation of connexin43 (Cx43) and that Cx43 …

Background Altered expression and distribution of gap junctions might provide substrates for
abnormal conduction and arrhythmogenesis in the heart, but little is known about the …

Connexin (Cx43)-formed channels have been linked to cardiac arrhythmias and diseases of
the heart associated with myocardial tissue loss and fibrosis. These pathologies include …