Objectives: To measure tissue glucocorticoid sensitivity in patients with septic shock and
determine its relationship to standard measurements of adrenal function and of outcome …

Objective There is mounting evidence showing the value of low-dose corticosteroids in
patients with septic shock requiring vasopressor therapy. It remains unclear whether adrenal …

Background A protective role for glucocorticoid therapy in animal models of sepsis was
shown many decades ago. In human sepsis, there is new interest in glucocorticoid therapy …

The use of glucocorticoids (corticotherapy) in severe sepsis is one of the main controversial
issues in critical care medicine. These agents were commonly used to treat sepsis until the …

Objective: To evaluate the concept of relative adrenal insufficiency necessitating
corticosteroid therapy in septic shock. Design: Retrospective study. Setting: Medical-surgical …

Glucocorticoid insufficiency in patients who present to the... : Critical Care Medicine
Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: A …

The concept of relative adrenal insufficiency in patients with severe sepsis continues to be
controversial. This arises in part from the lack of an accepted “gold standard” for the …

BACKGROUND AND OBJECTIVES: Corticosteroids were introduced in the treatment of
severe infection as early as in the nineteen forties. Several" negative" randomized controlled …

Objective: To compare a low-dose (1 μg) corticotropin stimulation test with the more
standard (250 μg) test for the diagnosis of relative adrenal insufficiency. Design: Diagnostic …

Objective: To refine the value of baseline and adrenocorticotropin hormone (ACTH)-
stimulated cortisol levels in relation to mortality from severe sepsis or septic shock. Design …