Polymerase Transcriptase Release Factor (PTRF) Anchors MG53 Protein to Cell Injury Site for Initiation of Membrane Repair*♦
Plasma membrane repair is an essential process for maintenance of homeostasis at the
cellular and tissue levels, whereas compromised repair capacity contributes to degenerative …
cellular and tissue levels, whereas compromised repair capacity contributes to degenerative …
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy
N Weisleder, N Takizawa, P Lin, X Wang… - Science translational …, 2012 - science.org
Mitsugumin 53 (MG53), a muscle-specific TRIM family protein, is an essential component of
the cell membrane repair machinery. Here, we examined the translational value of targeting …
the cell membrane repair machinery. Here, we examined the translational value of targeting …
MG53 nucleates assembly of cell membrane repair machinery
Dynamic membrane repair is essential not only for long-term maintenance of cellular
integrity but also for recovery from acute cell injury. While compromised membrane repair …
integrity but also for recovery from acute cell injury. While compromised membrane repair …
Visualization of MG53-mediated cell membrane repair using in vivo and in vitro systems
Repair of acute injury to the cell membrane is an elemental process of normal cellular
physiology, and defective membrane repair has been linked to many degenerative human …
physiology, and defective membrane repair has been linked to many degenerative human …
Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair
M Hwang, J Ko, N Weisleder… - American Journal of …, 2011 - journals.physiology.org
We recently discovered that MG53, a muscle-specific tripartite motif (TRIM) family protein,
functions as a sensor of oxidation to nucleate the assembly of cell membrane repair …
functions as a sensor of oxidation to nucleate the assembly of cell membrane repair …
[HTML][HTML] Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair
Repair of injury to the plasma membrane is an essential mechanism for maintenance of
cellular homeostasis and integrity that involves coordinated movement of intracellular …
cellular homeostasis and integrity that involves coordinated movement of intracellular …
Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin
Defective membrane repair can contribute to the progression of muscular dystrophy.
Although mutations in caveolin-3 (Cav3) and dysferlin are linked to muscular dystrophy in …
Although mutations in caveolin-3 (Cav3) and dysferlin are linked to muscular dystrophy in …
Modulation of wound healing and scar formation by MG53 protein-mediated cell membrane repair
Cell membrane repair is an important aspect of physiology, and disruption of this process
can result in pathophysiology in a number of different tissues, including wound healing …
can result in pathophysiology in a number of different tissues, including wound healing …
Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair
N Weisleder, H Takeshima, J Ma - Communicative & integrative …, 2009 - Taylor & Francis
Repair of the plasma membrane following damage is an important aspect of normal cellular
physiology, and disruption of this process is observed in many pathologic states. In a recent …
physiology, and disruption of this process is observed in many pathologic states. In a recent …
Enhancing muscle membrane repair by gene delivery of MG53 ameliorates muscular dystrophy and heart failure in δ-Sarcoglycan-deficient hamsters
Muscular dystrophies (MDs) are caused by genetic mutations in over 30 different genes,
many of which encode for proteins essential for the integrity of muscle cell structure and …
many of which encode for proteins essential for the integrity of muscle cell structure and …