Understanding mast cell heterogeneity at single cell resolution
Mast cells (MC) s are evolutionarily conserved, tissue-resident immune cells with diverse
roles in allergy, cancer, and protection from infection by helminths and microorganisms. The …
roles in allergy, cancer, and protection from infection by helminths and microorganisms. The …
Defining mast cell differentiation and heterogeneity through single-cell transcriptomics analysis
Mast cells (MCs) are widely recognized as central effector cells during type 2 inflammatory
reactions and thought to also play a role in innate immune responses, wound healing, and …
reactions and thought to also play a role in innate immune responses, wound healing, and …
Is it time for a new classification of mast cells? What do we know about mast cell heterogeneity?
B Frossi, F Mion, R Sibilano, L Danelli… - Immunological …, 2018 - Wiley Online Library
Mast cells (MC s) are derived from committed precursors that leave the hematopoietic tissue,
migrate in the blood, and colonize peripheral tissues where they terminally differentiate …
migrate in the blood, and colonize peripheral tissues where they terminally differentiate …
Quantitative in-depth analysis of the mouse mast cell transcriptome reveals organ-specific mast cell heterogeneity
Mast cells (MCs) are primarily resident hematopoietic tissue cells that are localized at
external and internal surfaces of the body where they act in the first line of defense. MCs are …
external and internal surfaces of the body where they act in the first line of defense. MCs are …
Selected recent advances in understanding the role of human mast cells in health and disease
Mast cells are highly granular tissue-resident cells and key drivers of inflammation,
particularly in allergies as well as in other inflammatory diseases. Most mast cell research …
particularly in allergies as well as in other inflammatory diseases. Most mast cell research …
Mast cells in inflammation and disease: recent progress and ongoing concerns
Mast cells have existed long before the development of adaptive immunity, although they
have been given different names. Thus, in the marine urochordate Styela plicata, they have …
have been given different names. Thus, in the marine urochordate Styela plicata, they have …
Mast cells as drivers of disease and therapeutic targets
Mast cells (MCs) contribute to the pathogenesis of a multitude of diseases that include MC-
driven disorders such as urticaria, type I allergies, and mastocytosis as well as autoimmune …
driven disorders such as urticaria, type I allergies, and mastocytosis as well as autoimmune …
The transcriptional program, functional heterogeneity, and clinical targeting of mast cells
Mast cells are unique tissue-resident immune cells that express an array of receptors that
can be activated by several extracellular cues, including antigen–immunoglobulin E (IgE) …
can be activated by several extracellular cues, including antigen–immunoglobulin E (IgE) …
The ingenious mast cell: Contemporary insights into mast cell behavior and function
Mast cells are (in) famous for their role in allergic diseases, but the physiological and
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …
Landscape of mast cell populations across organs in mice and humans
M Tauber, L Basso, J Martin, L Bostan… - Journal of Experimental …, 2023 - rupress.org
Mast cells (MCs) are tissue-resident immune cells that exhibit homeostatic and neuron-
associated functions. Here, we combined whole-tissue imaging and single-cell RNA …
associated functions. Here, we combined whole-tissue imaging and single-cell RNA …