Tissue hypoxia induces reprogramming of cell metabolism and may result in normal cell
transformation and cancer progression. Hypoxia-inducible factor 1-alpha (HIF-1α), the key …

Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of
target genes involved in crucial aspects of cancer development. This study investigated the …

Background The transcriptional factor hypoxia-inducible factor 1α (HIF-1α) controls
angiogenesis and metabolism by upregulating hypoxia-induced genes, such as the vascular …

AIM To investigate the relationship between hypoxia-inducible factor-1α (HIF-1α), prolyl 4-
hydroxylase beta (P4HB) expression, and clinicopathologic parameters, as well as the …

Hypoxia is a common environmental stress that influences signaling pathways and cells
function, which through initiating intracellular signaling pathways and hence leading to the …

Gastric cancer (GC) is a common tumor‐associated lethal disease, and invasiveness and
metastasis are primary challenges in its clinical treatment. Hypoxia microenvironment …

In view of the high incidence of gastric cancer and the functions of hypoxia-inducible factor
1α (HIF-1α), our study aimed to investigate the functionality of HIF-1α in gastric cancer, and …

Objectives: Tumor hypoxia confers poor prognosis of a wide range of solid tumors due to
increased malignancy, increased likelihood of metastasis and treatment resistance. The aim …

Background: The underlying mechanisms involved in the activation of hypoxia-inducible
factor-1 (HIF-1) in gastric cancer remain unclear. As nuclear factor-κB (NF-κB) as well as HIF …

Hypoxia inducible factor-1 (HIF-1) monitors the cellular response to the oxygen levels in
solid tumors. Under hypoxia conditions, HIF-1α protein is stabilized and forms a heterodimer …