Nanoenzyme-reinforced injectable hydrogel for healing diabetic wounds infected with multidrug resistant bacteria

S Wang, H Zheng, L Zhou, F Cheng, Z Liu, H Zhang… - Nano …, 2020 - ACS Publications
Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-
resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound …

Biomimetic Nanozyme-Decorated Hydrogels with H2O2-Activated Oxygenation for Modulating Immune Microenvironment in Diabetic Wound

Y Zhao, D Wang, T Qian, J Zhang, Z Li, Q Gong… - ACS …, 2023 - ACS Publications
Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels
are promising systems for DFU-based wound management, their effectiveness is often …

Bio-fabricated nanocomposite hydrogel with ROS scavenging and local oxygenation accelerates diabetic wound healing

Y Pu, P Wang, R Yang, X Tan, T Shi, J Ma… - Journal of Materials …, 2022 - pubs.rsc.org
Chronic wounds, especially diabetic wounds, involve abnormally long inflammatory periods
due to their pathological microenvironment of high reactive oxygen species (ROS) levels …

Engineering bacteria‐activated multifunctionalized hydrogel for promoting diabetic wound healing

Y Lu, H Li, J Wang, M Yao, Y Peng, T Liu… - Advanced Functional …, 2021 - Wiley Online Library
Engineering therapeutic angiogenesis in impaired tissues is critical for chronic wound
healing. Materials can be engineered to deliver specific biological cues that enhance …

Diabetes immunity-modulated multifunctional hydrogel with cascade enzyme catalytic activity for bacterial wound treatment

M Deng, M Zhang, R Huang, H Li, W Lv, X Lin… - Biomaterials, 2022 - Elsevier
Diabetes immunity-modulated wound treatment in response to the varied
microenvironments at different stages remains an urgent challenge. Herein, glucose oxidase …

All‐in‐one: multifunctional hydrogel accelerates oxidative diabetic wound healing through timed‐release of exosome and fibroblast growth factor

Y Xiong, L Chen, P Liu, T Yu, C Lin, C Yan, Y Hu… - Small, 2022 - Wiley Online Library
The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic
wounds characterized by multiple drug‐resistant bacterial infections, angiopathy, and …

Responsive multifunctional hydrogels emulating the chronic wounds healing cascade for skin repair

W Zhang, W Liu, L Long, S He, Z Wang, Y Liu… - Journal of Controlled …, 2023 - Elsevier
It remains challenging to cure chronic diabetic wounds due to its' harsh microenvironment
and poor tissue regeneration ability. At present, bacteria elimination, inflammatory response …

Bioactive injectable hydrogel dressings for bacteria-infected diabetic wound healing: a “pull–push” approach

K Zhang, C Yang, C Cheng, C Shi, M Sun… - … applied materials & …, 2022 - ACS Publications
Chronic diabetic wound healing remains a challenge due to the existence of excessive
danger molecules and bacteria in the inflammatory microenvironment. There is an urgent …

A Nanozyme‐Immobilized Hydrogel with Endogenous ROS‐Scavenging and Oxygen Generation Abilities for Significantly Promoting Oxidative Diabetic Wound …

Z Li, Y Zhao, H Huang, C Zhang, H Liu… - Advanced …, 2022 - Wiley Online Library
Non‐healing wound is a common complication of diabetic patients associated with high
morbidity and mortality. Engineered therapeutic hydrogels have enviable advantages in …

Development of a microenvironment-responsive hydrogel promoting chronically infected diabetic wound healing through sequential hemostatic, antibacterial, and …

C Guo, Y Wu, W Li, Y Wang, Q Kong - ACS Applied Materials & …, 2022 - ACS Publications
Microenvironment-responsive hydrogels present high potential in treating refractory wounds
due to their capability of on-demand drug release. In this study, a specially designed …