Background Our aim was to identify which clinical features have value in confirming or
excluding the possibility of serious infection in children presenting to ambulatory care …

Objective To collate all available evidence on the diagnostic value of laboratory tests for the
diagnosis of serious infections in febrile children in ambulatory settings. Design Systematic …

Background Although the vast majority of children with acute infection are managed at
home, this is one of the most common problems encountered in children attending …

Background Serious infections in children (sepsis, meningitis, pneumonia, pyelonephritis,
osteomyelitis, and cellulitis) are associated with considerable mortality and morbidity. In …

OBJECTIVES: To assess the performance of the Yale Observation Scale (YOS) score and
unstructured clinician suspicion to identify febrile infants≤ 60 days of age with and without …

It is estimated that 5 million deaths occur in the neonatal period annually. Of these,∼ 97%
are in developing countries and> 40% are believed to be caused by infection. 1 In …

Objectives: To determine whether vital signs identify children with serious infections, and to
compare their diagnostic value with that of the Manchester triage score (MTS) and National …

Background A physician is frequently unable to distinguish bacterial from viral infections.
ImmunoXpert is a novel assay combining three proteins: tumour necrosis factor-related …

BACKGROUND: Improving the diagnosis of serious bacterial infections (SBIs) in the
children's emergency department is a clinical priority. Early recognition reduces morbidity …

Background: Sepsis, meningitis and pneumonia annually kill 1.1 million neonates in
developing countries; most deaths occur at home. Objectives: To develop simple clinical …