Streptomycetes are prominent sources of bioactive natural products, but metabolic
engineering of the natural products of these organisms is greatly hindered by relatively …

Bacteria of the order Actinomycetales are one of the most important sources of
pharmacologically active and industrially relevant secondary metabolites. Unfortunately …

Actinobacteria, particularly those of genus Streptomyces, remain invaluable hosts for the
discovery and engineering of natural products and their cognate biosynthetic pathways …

Application of the well‐characterized Streptococcus pyogenes CRISPR‐Cas9 system in
actinomycetes streptomycetes has enabled high‐efficiency multiplex genome editing and …

Streptomyces has a strong capability for producing a large number of bioactive natural
products and remains invaluable as a source for the discovery of novel drug leads. Although …

Streptomycetes have a strong ability to produce a vast array of bioactive natural products
(NPs) widely used in agriculture and veterinary/human medicine. The recently developed …

The RNA-guided DNA editing technology CRISPRs (clustered regularly interspaced short
palindromic repeats)/Cas9 had been used to introduce double-stranded breaks into …

Covering: up to December 2018 This article aims to highlight advantages, drawbacks and
issues that users should consider when implementing the use of CRISPR/Cas9-tools for …

The genome of Streptomyces encodes a high number of natural product (NP) biosynthetic
gene clusters (BGCs). Most of these BGCs are not expressed or are poorly expressed …

Streptomyces strains produce a great number of valuable natural products. With the
development of genome sequencing, a vast number of biosynthetic gene clusters with high …