Monozygotic (MZ) twins are partially concordant for most complex diseases, including
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability …

Background Rheumatoid arthritis is a common autoimmune disorder influenced by both
genetic and environmental factors. Epigenome-wide association studies can identify …

Systemic lupus erythematosus (SLE or lupus) is a heterogeneous autoimmune disease
characterized by the involvement of multiple organs and the production of antinuclear …

Objective Systemic lupus erythematosus (SLE) has limited monozygotic twin concordance,
implying a role for pathogenic factors other than genetic variation, such as epigenetic …

Changes to the DNA methylome have been described in patients with rheumatoid arthritis
(RA). In previous work, we reported genome-wide methylation differences in T-lymphocyte …

Systemic lupus erythematosus is a chronic-relapsing autoimmune disease of incompletely
understood etiology. Recent evidence strongly supports an epigenetic contribution to the …

Systemic lupus erythematosus is an autoimmune disease characterized by multi-system
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …

Objectives Systemic lupus erythematosus (SLE) is a chronic autoimmune condition with
heterogeneous presentation and complex aetiology where DNA methylation changes are …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by
aberrant immune responses directed against cells and tissues, resulting in inflammation and …

Recent evidence suggests that neutrophils play an important role in the pathogenesis of
lupus. The goal of this study was to characterize the epigenetic architecture, by studying the …