Indicator dilution theory predicts that the first-pass pulmonary and systemic arterial
concentrations of a drug will be inversely related to the cardiac output. For high-clearance …

This study was designed to investigate if propofol produced cardiovascular effects by
indirect actions or by indirect actions secondary to depression of the central nervous system …

Background As propofol is a high-clearance drug, plasma propofol concentrations can be
influenced by cardiac output (CO), which can easily change in response to several factors. If …

A marked reduction in the dose of propofol required to achieve the onset of anesthesia with
slower administration rates has previously been reported, but the mechanism of this …

To establish anesthesia with minimal respiratory and cardiovascular depression using
propofol, the effects of varying the rate of delivery on anesthetic induction dose requirements …

The determinants of induction of anaesthesia with propofol, and their implications for dose
requirements, were analysed using a physiological model of the process, validated …

The hemodynamic effects of an induction dose of propofol, 2.5 mg/kg, or etomidate, 0.3
mg/kg, were studied in eight dogs. In addition, cardiodynamic changes were measured …

Background The influence of infusion rate on the induction dose-response relation has not
been investigated over a wide range of infusion rates. In this study, the authors defined the …

Prolonged, stable, non-recovery anaesthesia is required for the assessment of the effects of
novel compounds on the cardiovascular system. A comparison of injectable anaesthetic …

We have measured whole blood concentrations and pharmacokinetics of propofol
administered as a constant rate infusion during cardiac surgery. Ten patients undergoing …