Intracellular ATP does not inhibit Slo2.1 K+ channels

P Garg, MC Sanguinetti - Physiological reports, 2014 - Wiley Online Library
Under normal physiological conditions, the open probability of Slo2. 1 K+ channels is low.
Elevation of cytosolic [Na+] and [Cl−] caused by ischemia or rapid electrical pacing of cells …

Identification of the intracellular Na+ sensor in Slo2. 1 potassium channels

SJ Thomson, A Hansen, MC Sanguinetti - Journal of Biological Chemistry, 2015 - ASBMB
Slo2 potassium channels have a very low open probability under normal physiological
conditions, but are readily activated in response to an elevated [Na+] i (eg during ischemia) …

SLO2 channels are inhibited by all divalent cations that activate SLO1 K+ channels

G Budelli, Q Sun, J Ferreira, A Butler, CM Santi… - Journal of Biological …, 2016 - ASBMB
Two members of the family of high conductance K+ channels SLO1 and SLO2 are both
activated by intracellular cations. However, SLO1 is activated by Ca 2+ and other divalent …

Activation of Slo2. 1 channels by niflumic acid

L Dai, V Garg, MC Sanguinetti - Journal of General Physiology, 2010 - rupress.org
Slo2. 1 channels conduct an outwardly rectifying K+ current when activated by high [Na+] i.
Here, we show that gating of these channels can also be activated by fenamates such as …

Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine

QY Tang, Z Zhang, XM Xia, CJ Lingle - Channels, 2010 - Taylor & Francis
pH-regulated Slo3 channels, perhaps exclusively expressed in mammalian sperm, may play
a role in alkalization-mediated K+ fluxes associated with sperm capacitation. The Slo3 …

pH-regulated Slo3 K+ Channels: Properties of Unitary Currents

X Zhang, X Zeng, XM Xia, CJ Lingle - The Journal of general physiology, 2006 - rupress.org
Here we have examined the voltage and pH dependence of unitary Slo3 channels and used
analysis of current variance to define Slo3 unitary current properties over a broader range of …

PIP2 modulation of Slick and Slack K+ channels

M de los Angeles Tejada, LJ Jensen… - … and biophysical research …, 2012 - Elsevier
Slick and Slack are members of the Slo family of high-conductance potassium channels.
These channels are activated by Na+ and Cl− and are highly expressed in the CNS, where …

Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents

X Zhang, X Zeng, CJ Lingle - The Journal of general physiology, 2006 - rupress.org
The mouse Slo3 gene (KCNMA3) encodes a K+ channel that is regulated by changes in
cytosolic pH. Like Slo1 subunits responsible for the Ca2+ and voltage-activated BK-type …

[HTML][HTML] The β1 subunit of Na+/K+-ATPase interacts with BKCa channels and affects their steady-state expression on the cell surface

S Jha, SE Dryer - FEBS letters, 2009 - Elsevier
Large conductance Ca2+-activated K+ channels (BKCa) encoded by the Slo1 gene play a
role in the physiological regulation of many cell types. Here, we show that the β1 subunit of …

Mouse sperm K+ currents stimulated by pH and cAMP possibly coded by Slo3 channels

P Martínez-López, CM Santi, CL Treviño… - Biochemical and …, 2009 - Elsevier
Slo3 channels belong to the high conductance Slo K+ channel family. They are activated by
voltage and intracellular alkalinization, and have a K+/Na+ permeability ratio (PK/PNa) of …