It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are
completely absent in rodent brains. We report here that an aged wild-type South American …

Recently it has been shown that over 3-year-old wild-type South American rodents, Octodon
degus, the “common degu” or degu, of their own accord develop Alzheimer's disease …

Alzheimer's disease (AD) is characterized by the extensive deposition of the 42‐amino‐acid
β‐amyloid or A4 protein in neuritic plaques and neurofibrillary tangles within the brain. This …

We characterized senile plaques (SPs) immunohistochemically in cynomolgus monkey
brains and also examined age-related biochemical changes of Alzheimer's disease (AD) …

Senile plaques characterized by β-amyloid protein (Aβ) deposits around dystrophic neurites
and glial cells are more abundant in the cerebral cortical parenchyma of Alzheimer's …

Based on the homology of human and monkey amyloid precursor proteins and the derived β-
amyloid peptides (Aβ) the investigation of brains from old monkeys might be useful for the …

Accumulation of amyloid-β (Aβ) peptides in the brain has been suggested to be the primary
event in sequential progression of Alzheimer's disease (AD). Here, we use Drosophila to …

A central pathological feature of Alzheimer's disease is the profuse deposition of amyloid-β
protein (Aβ) in the brain parenchyma and vessel walls. Aβ also forms deposits in the brains …

The study of Alzheimer's disease (AD) pathogenesis requires the use of animal models that
develop some amount of amyloid pathology in the brain. Aged canines (beagles) naturally …

While aged monkeys of several species show cerebral amyloid deposition in senile plaques
and blood vessels similar to that seen in human aging and Alzheimer's disease (AD) …