Genetic or other causation should not change the clinical diagnosis of cerebral palsy
AH MacLennan, S Lewis… - Journal of child …, 2019 - journals.sagepub.com
High throughput sequencing is discovering many likely causative genetic variants in
individuals with cerebral palsy. Some investigators have suggested that this changes the …
individuals with cerebral palsy. Some investigators have suggested that this changes the …
Yield of clinically reportable genetic variants in unselected cerebral palsy by whole genome sequencing
CL van Eyk, DL Webber, AE Minoche… - NPJ genomic …, 2021 - nature.com
Cerebral palsy (CP) is the most common cause of childhood physical disability, with
incidence between 1/500 and 1/700 births in the developed world. Despite increasing …
incidence between 1/500 and 1/700 births in the developed world. Despite increasing …
Genetic testing in individuals with cerebral palsy
HJ May, JA Fasheun, JM Bain… - … Medicine & Child …, 2021 - Wiley Online Library
AIM To determine which patients with cerebral palsy (CP) should undergo genetic testing,
we compared the rate of likely causative genetic variants from whole‐exome sequencing in …
we compared the rate of likely causative genetic variants from whole‐exome sequencing in …
Genomic analysis identifies masqueraders of full‐term cerebral palsy
Y Takezawa, A Kikuchi, K Haginoya… - Annals of Clinical …, 2018 - Wiley Online Library
Objective Cerebral palsy is a common, heterogeneous neurodevelopmental disorder that
causes movement and postural disabilities. Recent studies have suggested genetic …
causes movement and postural disabilities. Recent studies have suggested genetic …
Genetic insights into the causes and classification of the cerebral palsies
Cerebral palsy—the most common physical disability of childhood—is a clinical diagnosis
encompassing a heterogeneous group of neurodevelopmental disorders that cause …
encompassing a heterogeneous group of neurodevelopmental disorders that cause …
Insights from genetic studies of cerebral palsy
SA Lewis, S Shetty, BA Wilson, AJ Huang… - Frontiers in …, 2021 - frontiersin.org
Cohort-based whole exome and whole genome sequencing and copy number variant
(CNV) studies have identified genetic etiologies for a sizable proportion of patients with …
(CNV) studies have identified genetic etiologies for a sizable proportion of patients with …
Redefining cerebral palsies as a diverse group of neurodevelopmental disorders with genetic aetiology
Cerebral palsy is a clinical descriptor covering a diverse group of permanent, non-
degenerative disorders of motor function. Around one-third of cases have now been shown …
degenerative disorders of motor function. Around one-third of cases have now been shown …
[HTML][HTML] Cerebral palsy: causes, pathways, and the role of genetic variants
AH MacLennan, SC Thompson, J Gecz - American journal of obstetrics and …, 2015 - Elsevier
Cerebral palsy (CP) is heterogeneous with different clinical types, comorbidities, brain
imaging patterns, causes, and now also heterogeneous underlying genetic variants. Few …
imaging patterns, causes, and now also heterogeneous underlying genetic variants. Few …
[HTML][HTML] Atypical cerebral palsy: genomics analysis enables precision medicine
Purpose The presentation and etiology of cerebral palsy (CP) are heterogeneous.
Diagnostic evaluation can be a prolonged and expensive process that might remain …
Diagnostic evaluation can be a prolonged and expensive process that might remain …
Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy
G McMichael, MN Bainbridge, E Haan, M Corbett… - Molecular …, 2015 - nature.com
Cerebral palsy (CP) is a common, clinically heterogeneous group of disorders affecting
movement and posture. Its prevalence has changed little in 50 years and the causes remain …
movement and posture. Its prevalence has changed little in 50 years and the causes remain …