Gene therapy is the targeted insertion of missing or absent genetic materials into the cells
with aims of preventing or curing disease. As such, the successful delivery of site and …

Targeting, safety, scalability, and storage stability of vectors are still challenges in the field of
nucleic acid delivery for gene therapy. Silica-based nanoparticles have been widely studied …

The development of nucleic acid‐based drugs holds great promise for therapeutic
applications, but their effective delivery into cells is hindered by poor cellular membrane …

Silica nanoparticles are attractive candidates for the development of safe and efficient non-
viral gene carriers, owing to their controlled morphologies, potential of facile surface …

Gene therapy has attracted much attention in modern society and provides a promising
approach for treating genetic disorders, diseases and cancers. Safe and effective vectors …

Silica-based nanoparticles are promising carriers for gene delivery applications. To gain
insights into the effect of particle size on gene transfection efficiency, amine-modified …

Silica nanoparticles (SNPs) have attracted widespread attention as biocompatible and
efficient nanocarriers for gene delivery. The physicochemical properties of SNPs such as …

Advances in gene therapy have been foreshadowing its potential for the treatment of a vast
range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and …

Repairing genetic defects using exogenous DNA is a major challenge the science is
currently facing. This requires the design of vectors that can effectively encapsulate, protect …

The transport of nucleic acid-based reagents is predicated upon developing structurally
stable delivery systems that can preferentially bind and protect DNA and RNA, and release …