[引用][C] Development of silica based nanoparticles for plasmid DNA delivery
E Hines - 2021 - espace.library.uq.edu.au
Gene therapy is the targeted insertion of missing or absent genetic materials into the cells
with aims of preventing or curing disease. As such, the successful delivery of site and …
with aims of preventing or curing disease. As such, the successful delivery of site and …
Biodegradable silica nanoparticles for efficient linear DNA gene delivery
Targeting, safety, scalability, and storage stability of vectors are still challenges in the field of
nucleic acid delivery for gene therapy. Silica-based nanoparticles have been widely studied …
nucleic acid delivery for gene therapy. Silica-based nanoparticles have been widely studied …
Engineered Silica Nanoparticles for Nucleic Acid Delivery
The development of nucleic acid‐based drugs holds great promise for therapeutic
applications, but their effective delivery into cells is hindered by poor cellular membrane …
applications, but their effective delivery into cells is hindered by poor cellular membrane …
The shape and size effects of polycation functionalized silica nanoparticles on gene transfection
X Lin, N Zhao, P Yan, H Hu, FJ Xu - Acta biomaterialia, 2015 - Elsevier
Silica nanoparticles are attractive candidates for the development of safe and efficient non-
viral gene carriers, owing to their controlled morphologies, potential of facile surface …
viral gene carriers, owing to their controlled morphologies, potential of facile surface …
Recent advances in the rational design of silica-based nanoparticles for gene therapy
Gene therapy has attracted much attention in modern society and provides a promising
approach for treating genetic disorders, diseases and cancers. Safe and effective vectors …
approach for treating genetic disorders, diseases and cancers. Safe and effective vectors …
Size-dependent gene delivery of amine-modified silica nanoparticles
Silica-based nanoparticles are promising carriers for gene delivery applications. To gain
insights into the effect of particle size on gene transfection efficiency, amine-modified …
insights into the effect of particle size on gene transfection efficiency, amine-modified …
Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery
Silica nanoparticles (SNPs) have attracted widespread attention as biocompatible and
efficient nanocarriers for gene delivery. The physicochemical properties of SNPs such as …
efficient nanocarriers for gene delivery. The physicochemical properties of SNPs such as …
[HTML][HTML] Silica-based gene delivery systems: From design to therapeutic applications
Advances in gene therapy have been foreshadowing its potential for the treatment of a vast
range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and …
range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and …
[HTML][HTML] One-pot synthesis of compact DNA silica particles for gene delivery and extraordinary DNA preservation
A Ramos-Valle, L Marín-Caba, LG Hevia… - Materials Today …, 2023 - Elsevier
Repairing genetic defects using exogenous DNA is a major challenge the science is
currently facing. This requires the design of vectors that can effectively encapsulate, protect …
currently facing. This requires the design of vectors that can effectively encapsulate, protect …
Silica nanoparticles as a delivery system for nucleic acid-based reagents
C Hom, J Lu, F Tamanoi - Journal of materials chemistry, 2009 - pubs.rsc.org
The transport of nucleic acid-based reagents is predicated upon developing structurally
stable delivery systems that can preferentially bind and protect DNA and RNA, and release …
stable delivery systems that can preferentially bind and protect DNA and RNA, and release …