Genetic variants and functional pathways associated with resilience to Alzheimer's disease
Approximately 30% of older adults exhibit the neuropathological features of Alzheimer's
disease without signs of cognitive impairment. Yet, little is known about the genetic factors …
disease without signs of cognitive impairment. Yet, little is known about the genetic factors …
Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease
JM Eissman, L Dumitrescu, ER Mahoney, AN Smith… - Brain, 2022 - academic.oup.com
Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the
presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are …
presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are …
Asymptomatic Alzheimer disease: defining resilience
Objective: To define robust resilience metrics by leveraging CSF biomarkers of Alzheimer
disease (AD) pathology within a latent variable framework and to demonstrate the ability of …
disease (AD) pathology within a latent variable framework and to demonstrate the ability of …
[HTML][HTML] Translational approaches to understanding resilience to Alzheimer's disease
Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
Cognitive resilience to Alzheimer's disease pathology in the human brain
EJ Aiello Bowles, PK Crane, RL Walker… - Journal of …, 2019 - content.iospress.com
Background: Past research has focused on risk factors for developing dementia, with
increasing recognition of “resilient” people who live to old age with intact cognitive function …
increasing recognition of “resilient” people who live to old age with intact cognitive function …
Resilient brain aging: characterization of discordance between Alzheimer's disease pathology and cognition
S Negash, RS Wilson, SE Leurgans… - Current Alzheimer …, 2013 - ingentaconnect.com
Background: Although it is now evident that normal cognition can occur despite significant
AD pathology, few studies have attempted to characterize this discordance, or examine …
AD pathology, few studies have attempted to characterize this discordance, or examine …
The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies
EM Arenaza-Urquijo, SA Przybelski, TL Lesnick… - Brain, 2019 - academic.oup.com
Research into cognitive resilience imaging markers may help determine the clinical
significance of Alzheimer's disease pathology among older adults over 80 years (80+). In …
significance of Alzheimer's disease pathology among older adults over 80 years (80+). In …
Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease
Although neuritic plaques and neurofibrillary tangles in older adults are correlated with
cognitive impairment and severity of dementia, it has long been recognized that the …
cognitive impairment and severity of dementia, it has long been recognized that the …
A genome-wide scan for common variants affecting the rate of age-related cognitive decline
Age-related cognitive decline is likely promoted by accumulated brain injury due to chronic
conditions of aging, including neurodegenerative and vascular disease. Because common …
conditions of aging, including neurodegenerative and vascular disease. Because common …
[HTML][HTML] Improving the resistance and resilience framework for aging and dementia studies
EM Arenaza-Urquijo, P Vemuri - Alzheimer's research & therapy, 2020 - Springer
Background The" resistance vs resilience" to Alzheimer's disease (AD) framework (coping vs
avoiding) has gained interest in the field in the last year. In this viewpoint, our effort is (i) to …
avoiding) has gained interest in the field in the last year. In this viewpoint, our effort is (i) to …
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