Approximately 30% of older adults exhibit the neuropathological features of Alzheimer's
disease without signs of cognitive impairment. Yet, little is known about the genetic factors …

Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the
presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are …

Objective: To define robust resilience metrics by leveraging CSF biomarkers of Alzheimer
disease (AD) pathology within a latent variable framework and to demonstrate the ability of …

Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …

Background: Past research has focused on risk factors for developing dementia, with
increasing recognition of “resilient” people who live to old age with intact cognitive function …

Background: Although it is now evident that normal cognition can occur despite significant
AD pathology, few studies have attempted to characterize this discordance, or examine …

Research into cognitive resilience imaging markers may help determine the clinical
significance of Alzheimer's disease pathology among older adults over 80 years (80+). In …

Although neuritic plaques and neurofibrillary tangles in older adults are correlated with
cognitive impairment and severity of dementia, it has long been recognized that the …

Age-related cognitive decline is likely promoted by accumulated brain injury due to chronic
conditions of aging, including neurodegenerative and vascular disease. Because common …

Background The" resistance vs resilience" to Alzheimer's disease (AD) framework (coping vs
avoiding) has gained interest in the field in the last year. In this viewpoint, our effort is (i) to …