Foldons, which are kinetically competent, quasi-independently folding units of a protein, may
be defined using energy landscape analysis. Foldons can be identified by maxima in a scan …

A lattice model of protein folding is developed to distinguish between amino acid sequences
that do and do not fold into unique conformations. Although Monte Carlo simulations provide …

The rapid folding of certain proteins can be described theoretically using an energy
landscape in the shape of a folding funnel. New techniques have allowed the examination of …

The understanding, and even the description of protein folding is impeded by the complexity
of the process. Much of this complexity can be described and understood by taking a …

I. INTRODUCTION The study of the rapidly increasing number of protein structures has led
(Levitt and Chothia, 1976; Richardson, 1977, 1981) to a very important generalization: in …

Background: Although small proteins may fold in an apparent two-state manner, most
studies of protein folding reveal transient intermediates. The 'molten globule'has been …

We present a method to identify all compact, contiguous-chain, structural units in a globular
protein from x-ray coordinates. These units are then used to describe a complete set of …

Publisher Summary This chapter presents an overview of the theoretical aspects of the “new
view” of protein folding based on the energy landscape theory and the funnel concept. The …

This Commentary clarifies the meaning of the funnel diagram, which has been widely cited
in papers on protein folding. To aid in the analysis of the funnel diagram, this Commentary …

The hierarchical partition function formalism for protein folding developed earlier has been
extended through the use of three-dimensional polar and apolar contact plots. For each …