Mannose-binding lectin and its genetic variants

P Garred, F Larsen, J Seyfarth, R Fujita… - Genes & Immunity, 2006 - nature.com
Mannose-binding lectin (MBL) is a collagen-like serum protein that mediates activation of
the complement system and is of importance for host defence. Common variant alleles …

Mannose-binding lectin genetics: from A to Z

P Garred - Biochemical Society Transactions, 2008 - portlandpress.com
MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein. It
binds sugar structures on micro-organisms and on dying host cells and is one of the four …

Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity

LH Bouwman, BO Roep, A Roos - Human immunology, 2006 - Elsevier
Mannose-binding lectin (MBL) is a recognition molecule of the lectin pathway of complement
and a key component of innate immunity. MBL variant alleles have been described in the …

Mannose-binding lectin deficiency—revisited

P Garred, F Larsen, HO Madsen, C Koch - Molecular immunology, 2003 - Elsevier
There is an emerging interest for mannose-binding lectin (MBL) due to its role in innate
immunity. In this survey we present a mixture of old and new data describing the effect MBL …

Mannose binding lectin: genetics and autoimmune disease

A Tsutsumi, R Takahashi, T Sumida - Autoimmunity reviews, 2005 - Elsevier
Mannose binding lectin (MBL) is a serum protein with structure and functions similar to those
of complement factor C1q, and is a key molecule in innate immunity. Interestingly, absence …

Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection

T Bernig, JG Taylor, CB Foster, B Staats, M Yeager… - Genes & …, 2004 - nature.com
Human mannose-binding protein (MBL) is a component of innate immunity. To capture the
common genetic variants of MBL2, we resequenced a 10.0 kb region that includes MBL2 in …

The ambiguous role of mannose-binding lectin (MBL) in human immunity

N Kalia, J Singh, M Kaur - Open Medicine, 2021 - degruyter.com
Mannose-binding lectin (MBL) and lectin complement pathway have become targets of
increasing clinical interest. Many aspects of MBL have been recently explored, including the …

Mannose-binding lectin gene: polymorphisms in Japanese patients with systemic lupus erythematosus, rheumatoid arthritis and Sjögren's syndrome

A Tsutsumi, K Sasaki, N Wakamiya, K Ichikawa… - Genes & …, 2001 - nature.com
Mannose-binding lectin (MBL) is a key element of the innate immunity, with a structure
similar to complement C1q. Serum MBL levels are greatly affected by the polymorphisms of …

Analysis of the relationship between mannose‐binding lectin (MBL) genotype, MBL levels and function in an Australian blood donor population

RM Minchinton, MM Dean, TR Clark… - Scandinavian …, 2002 - Wiley Online Library
The mannose‐binding lectin (MBL) pathway of complement activation is an important
component of innate host defence. Numerous studies have described associations between …

Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein

F Larsen, HO Madsen, RB Sim, C Koch… - Journal of Biological …, 2004 - ASBMB
Deficiency of human mannose-binding lectin (MBL) caused by mutations in the coding part
of the MBL2 gene is associated with increased risk and severity of infections and …