[PDF] sciencedirect.com

Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells

D Li, B Mackowiak, TG Brayman, M Mitchell… - Biochemical …, 2015 - Elsevier
The constitutive androstane receptor (CAR) modulates the transcription of numerous genes
involving drug metabolism, energy homeostasis, and cell proliferation. Most functions of …
被引用次数：58 相关文章 所有 7 个版本
[PDF] nature.com

Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor

C Lynch, J Zhao, R Huang, J Xiao, L Li, S Heyward… - Scientific reports, 2015 - nature.com
The constitutive androstane receptor (CAR, NR1I3) plays a key role in governing the
transcription of numerous hepatic genes that involve xenobiotic metabolism/clearance …
被引用次数：43 相关文章 所有 11 个版本
[HTML] nih.gov

DL5050, a selective agonist for the human constitutive androstane receptor

D Liang, L Li, C Lynch, B Diethelm-Varela… - ACS Medicinal …, 2019 - ACS Publications
The constitutive androstane receptor (CAR) is a xenobiotic sensor governing the
transcription of genes involved in drug disposition, energy homeostasis, and cell …
被引用次数：12 相关文章 所有 5 个版本
[PDF] oup.comFull View

In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets

B Niu, DM Coslo, AR Bataille, I Albert… - Nucleic acids …, 2018 - academic.oup.com
The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor orchestrating
complex roles in cell and systems biology. Species differences in CAR's effector pathways …
被引用次数：36 相关文章 所有 11 个版本
[HTML] nih.gov

Nuclear translocation of adenoviral-enhanced yellow fluorescent protein-tagged-human constitutive androstane receptor (hCAR): a novel tool for screening hCAR …

H Li, T Chen, J Cottrell, H Wang - Drug metabolism and disposition, 2009 - ASPET
The constitutive androstane receptor [(CAR) NR1I3] is a hepatic transcription factor that
controls the expression of numerous drug-metabolizing enzymes and transporters in …
被引用次数：83 相关文章 所有 9 个版本
[PDF] jbc.orgFull View

Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling

Z Li, SM Kwon, D Li, L Li, X Peng, J Zhang… - Journal of Biological …, 2022 - ASBMB
The constitutive androstane receptor (CAR) is a nuclear receptor that plays a crucial role in
regulating xenobiotic metabolism and detoxification, energy homeostasis, and cell …
被引用次数：15 相关文章 所有 7 个版本
[HTML] nih.gov

Di (2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2

JG DeKeyser, MC Stagliano, SS Auerbach… - Molecular …, 2009 - ASPET
The human constitutive androstane receptor (CAR, CAR1) regulates the expression of
genes involved in xenobiotic metabolism in the liver. The CAR gene uses multiple …
被引用次数：83 相关文章 所有 12 个版本
[PDF] jst.go.jp

Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR)

J Imai, Y Yamazoe, K Yoshinari - Drug metabolism and pharmacokinetics, 2013 - Elsevier
Constitutive androstane receptor (CAR) plays vital roles in multiple liver functions including
xenobiotic and energy metabolisms, and also in hepatocarcinogenesis. CAR shows species …
被引用次数：20 相关文章 所有 9 个版本
[HTML] nih.gov

Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches

C Lynch, Y Pan, L Li, SS Ferguson, M Xia… - Pharmaceutical …, 2013 - Springer
Purpose The constitutive androstane receptor (CAR, NR1I3) is a xenobiotic sensor
governing the transcription of numerous hepatic genes associated with drug metabolism …
被引用次数：50 相关文章 所有 11 个版本
[HTML] nih.gov

RNA Sequencing Reveals Age and Species Differences of Constitutive Androstane Receptor–Targeted Drug-Processing Genes in the Liver

SL Cheng, TK Bammler, JY Cui - Drug Metabolism and Disposition, 2017 - ASPET
The constitutive androstane receptor (CAR/Nr1i3) is an important xenobiotic-sensing
nuclear receptor that is highly expressed in the liver and is well known to have species …
被引用次数：15 相关文章 所有 4 个版本