Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators
B Hommel, L Mukaremera, RJB Cordero… - PLoS …, 2018 - journals.plos.org
The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell
size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> …
size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> …
Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
N Trevijano-Contador, HC de Oliveira… - PLoS …, 2018 - journals.plos.org
Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of
the cells during infection. In particular, this process can occur by enlarging the size of the …
the cells during infection. In particular, this process can occur by enlarging the size of the …
The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis
IM Dambuza, T Drake, A Chapuis, X Zhou… - PLoS …, 2018 - journals.plos.org
Fungal cells change shape in response to environmental stimuli, and these morphogenic
transitions drive pathogenesis and niche adaptation. For example, dimorphic fungi switch …
transitions drive pathogenesis and niche adaptation. For example, dimorphic fungi switch …
The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2‐type responses
I García‐Barbazán, N Trevijano‐Contador… - Cellular …, 2016 - Wiley Online Library
Cryptococcus neoformans is a pathogenic yeast that can form titan cells in the lungs, which
are fungal cells of abnormal enlarged size. Little is known about the factors that trigger titan …
are fungal cells of abnormal enlarged size. Little is known about the factors that trigger titan …
Titan cells in Cryptococcus neoformans: cells with a giant impact
O Zaragoza, K Nielsen - Current opinion in microbiology, 2013 - Elsevier
Highlights•Cryptococcus has an unusual morphological transition in vivo to generate
enlarged titan cells.•Titan cells are greater than 15 μm in diameter, have a thick cell wall …
enlarged titan cells.•Titan cells are greater than 15 μm in diameter, have a thick cell wall …
Titan cells confer protection from phagocytosis in Cryptococcus neoformans infections
LH Okagaki, K Nielsen - Eukaryotic cell, 2012 - Am Soc Microbiol
The human fungal pathogen Cryptococcus neoformans produces an enlarged “titan” cell
morphology when exposed to the host pulmonary environment. Titan cells exhibit traits that …
morphology when exposed to the host pulmonary environment. Titan cells exhibit traits that …
Titan cell production enhances the virulence of Cryptococcus neoformans
Infection with Cryptococcus neoformans begins when desiccated yeast cells or spores are
inhaled and lodge in the alveoli of the lungs. A subset of cryptococcal cells in the lungs …
inhaled and lodge in the alveoli of the lungs. A subset of cryptococcal cells in the lungs …
Polyploid titan cells produce haploid and aneuploid progeny to promote stress adaptation
Cryptococcus neoformans is a major life-threatening fungal pathogen. In response to the
stress of the host environment, C. neoformans produces large polyploid titan cells. Titan cell …
stress of the host environment, C. neoformans produces large polyploid titan cells. Titan cell …
[HTML][HTML] Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection
Cryptococcus neoformans is a human fungal pathogen that often causes infections in
immunocompromised individuals. Upon inhalation into the lungs C. neoformans …
immunocompromised individuals. Upon inhalation into the lungs C. neoformans …
The Cryptococcus neoformans Titan Cell: From In Vivo Phenomenon to In Vitro Model
X Zhou, ER Ballou - Current Clinical Microbiology Reports, 2018 - Springer
Abstract Purpose of Review During infection, the human fungal pathogen Cryptococcus
neoformans undergoes an unusual change in size, from small haploid yeast to large …
neoformans undergoes an unusual change in size, from small haploid yeast to large …
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