The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the
urgent need to refocus on the question of which T-cell responses are required to control HIV …

CD8+ T cell recognition of virus-infected cells is characteristically restricted by major
histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction …

The complex interplay between the host immune response and HIV has been the subject of
intense research over the last 25 years. HIV and simian immunodeficiency virus (SIV) CD8+ …

Infection by human immunodeficiency virus type 1 (HIV-1) results in a progressive depletion
of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the …

We investigated the hypothesis that the correlation between the class I HLA types of an
individual and whether that individual spontaneously controls HIV-1 is mediated by the …

Certain major histocompatibility complex (MHC) class I alleles are strongly associated with
control of human immunodeficiency virus and simian immunodeficiency virus (SIV). CD8+ T …

Background It is generally accepted that CD8+ T cell responses play an important role in
control of immunodeficiency virus replication. The association of HLA-B27 and-B57 with …

An effective AIDS vaccine will need to protect against globally diverse isolates of HIV. To
address this issue in macaques, we administered a live-attenuated simian …

HIV-1-infected persons with HLA-B27 and-B57 alleles commonly remain healthy for
decades without antiretroviral therapy. Properties of CD8+ T cells restricted by these alleles …

ABSTRACT “Elite controllers” are individuals that durably control human immunodeficiency
virus or simian immunodeficiency virus replication without therapeutic intervention. The …