Three‐dimensional integrated functional, structural, and computational mapping to define the structural “fingerprints” of heart‐specific atrial fibrillation drivers in human …
Background Structural remodeling of human atria plays a key role in sustaining atrial
fibrillation (AF), but insufficient quantitative analysis of human atrial structure impedes the …
fibrillation (AF), but insufficient quantitative analysis of human atrial structure impedes the …
Atrial fibrillation driver mechanisms: insight from the isolated human heart
Although there have been great technological advances in the treatment of atrial fibrillation
(AF), current therapies remain limited due to a narrow understanding of AF mechanisms in …
(AF), current therapies remain limited due to a narrow understanding of AF mechanisms in …
Human atrial fibrillation drivers resolved with integrated functional and structural imaging to benefit clinical mapping
Objectives: This study sought to improve atrial fibrillation (AF) driver identification by
integrating clinical multielectrode mapping with driver fingerprints defined by high-resolution …
integrating clinical multielectrode mapping with driver fingerprints defined by high-resolution …
Fibrosis and atrial fibrillation: computerized and optical mapping: a view into the human atria at submillimeter resolution
Recent studies strongly suggest that the majority of atrial fibrillation (AF) patients with
diagnosed or subclinical cardiac diseases have established or even pre-existing fibrotic …
diagnosed or subclinical cardiac diseases have established or even pre-existing fibrotic …
[HTML][HTML] Slow conduction in the border zones of patchy fibrosis stabilizes the drivers for atrial fibrillation: insights from multi-scale human atrial modeling
Introduction: The genesis of atrial fibrillation (AF) and success of AF ablation therapy have
been strongly linked with atrial fibrosis. Increasing evidence suggests that patient-specific …
been strongly linked with atrial fibrosis. Increasing evidence suggests that patient-specific …
Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human …
Aims The complex architecture of the human atria may create physical substrates for
sustained re-entry to drive atrial fibrillation (AF). The existence of sustained, anatomically …
sustained re-entry to drive atrial fibrillation (AF). The existence of sustained, anatomically …
[HTML][HTML] Atrial heterogeneity generates re-entrant substrate during atrial fibrillation and anti-arrhythmic drug action: mechanistic insights from canine atrial models
Anti-arrhythmic drug therapy is a frontline treatment for atrial fibrillation (AF), but its success
rates are highly variable. This is due to incomplete understanding of the mechanisms of …
rates are highly variable. This is due to incomplete understanding of the mechanisms of …
Integration of high-resolution optical mapping and 3-dimensional micro-computed tomographic imaging to resolve the structural basis of atrial conduction in the …
Zhao et al Optical and Micro-CT Mapping of Human Atria 1515 (267 beats per minute),
whereas the LA was passively activated by the Bachmann bundle and septal pathways …
whereas the LA was passively activated by the Bachmann bundle and septal pathways …
[HTML][HTML] Image-based computational evaluation of the effects of atrial wall thickness and fibrosis on re-entrant drivers for atrial fibrillation
Introduction: Catheter ablation (CA) is a common treatment for atrial fibrillation (AF), but the
knowledge of optimal ablation sites, and hence clinical outcomes, are suboptimal …
knowledge of optimal ablation sites, and hence clinical outcomes, are suboptimal …
[HTML][HTML] In silico Comparison of Left Atrial Ablation Techniques That Target the Anatomical, Structural, and Electrical Substrates of Atrial Fibrillation
Catheter ablation therapy for persistent atrial fibrillation (AF) typically includes pulmonary
vein isolation (PVI) and may include additional ablation lesions that target patient-specific …
vein isolation (PVI) and may include additional ablation lesions that target patient-specific …
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