Injury to the epithelium is integral to the pathogenesis of many inflammatory lung diseases,
and epithelial repair is a critical determinant of clinical outcome. However, the signaling …

Repair of the lung epithelium after injury is integral to the pathogenesis and outcomes of
diverse inflammatory lung diseases. We previously reported that β-catenin signaling …

The primary function of neutrophils in host defense is to contain and eradicate invading
microbial pathogens. This is achieved through a series of swift and highly coordinated …

In the course of granulocyte-dominated lung inflammation, granulocytes migrate across the
endothelium and epithelium of the lung and cause severe tissue damage. To study this …

The Wnt/β-catenin signaling cascade activates genes that allow cells to adopt particular
identities throughout development. In adult self-renewing tissues like intestine and blood …

Neutrophil infiltration represents the early acute inflammatory response in acute lung injury.
The recruitment of neutrophils from the peripheral blood across the endothelial-epithelial …

Previous studies established that attenuating Wnt/β-catenin signaling limits lung fibrosis in
the bleomycin mouse model of this disease, but the contribution of this pathway to distinct …

Resolution of alveolar epithelial/capillary membrane damage after acute lung injury requires
coordinated and effective tissue repair to reestablish a functional alveolar epithelial/capillary …

Pulmonary fibrosis is a disease that results in loss of normal lung architecture, but the
signaling events that drive tissue destruction are incompletely understood. Wnt/β-catenin …

Rationale: Alveolar epithelial cells (AECs) play central roles in the response to lung injury
and the pathogenesis of pulmonary fibrosis. Objectives: We aimed to determine the role of β …