The classification of histamine receptors has to date been based on rigorous classical
pharmacological analysis, and as yet, the classification of the three histamine receptors that …

In this review the three main types of histamine receptors are discussed together with their
specific ligands. For the classical H 1-receptors much emphasis is put on the mechanism by …

Since the chemical synthesis of histamine by Windaus & Vogt (1) in 1907 and the classic
researches of Sir Henry Dale and his colleagues starting in 1910 (2, 3) on its physiological …

This article reviews the development of our knowledge of the actions of histamine which
have taken place during the course of the 20th century. Histamine has been shown to have …

It is clear from the preceding overview of histamine receptor pharmacology that research into
the pharmacology of histamine receptors is at an exciting stage of development. The rapid …

Several stages mark the development of our knowledge about histamine and its actions in
the body. First came its isolation, and the description of its pharmacological effects, akin on …

In this article, we review the recent developments in the field of histamine research. Besides
the description of pharmacological tools for the H1, H2 and H3 receptor, specific attention is …

Whether the job is waking the brain after a peaceful sleep, initiating gastric secretion when
dinner is served or orchestrating the elements of inflammation after a mosquito bite …

We report the discovery, tissue distribution and pharmacological characterization of a novel
receptor, which we have named H4. Like the three histamine receptors reported previously …

Histamine was already known as a chemical compound before its presence in mammals
was established early this century. It has lasted until the 1920s before a physiological role …