The number of well‐controlled hypertensives is unacceptably low worldwide. Respecting the
circadian variation of blood pressure, nontraditional antihypertensives, and treatment in …

Elevated heart rate is a risk factor for cardiovascular and all‐cause mortalities in the general
population and various cardiovascular pathologies. Insufficient heart rate decline during the …

The number of patients with well‐controlled hypertension is alarmingly low worldwide and
new approaches to treatment of increased blood pressure (BP) are being sought. Melatonin …

In experimental rodents, surgical removal of the pineal gland, the major source of circulating
melatonin, causes a gradual and sustained rise in blood pressure. Conversely, when …

Cardiovascular diseases account for approximately one‐third of all deaths each year. Of
this, hypertension accounts for approximately 9.4 million deaths. Melatonin, the primary …

Background Patients with nocturnal hypertension are at higher risk for cardiovascular
complications such as myocardial infarction and cerebrovascular insult. Published studies …

Increased blood pressure and reduced robustness of circadian rhythms are frequently
reported in elderly subjects. The present study was aimed to investigate whether such …

Patients with essential hypertension have disturbed autonomic cardiovascular regulation
and circadian pacemaker function. Recently, the biological clock was shown to be involved …

Circadian blood pressure variability and melatonin secretion are both regulated by the
biological clock. Several clinical trials have suggested that oral administration of exogenous …

Diurnal rhythms influence cardiovascular physiology, ie heart rate and blood pressure, and
they appear to also modulate the incidence of serious adverse cardiac events. Diurnal …