The availability of in vitro tools that are constructed on the basis of a detailed knowledge of
key aspects of gastrointestinal (GI) physiology and their impact on formulation performance …

Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is
critical to efficient drug development. Traditionally, in vitro evaluation of oral drug …

Background Biorelevant media for evaluation of dosage form performance in the
gastrointestinal lumen were first introduced in the late 1990s. Since then, a variety of …

OrBiTo is a new European project within the IMI programme in the area of oral
biopharmaceutics tools that includes world leading scientists from nine European …

Objectives To summarize the basis for and progress with the development of in-vitro–in-
silico–in-vivo (IV-IS-IV) relationships for oral dosage forms using physiologically based …

Individual pharmacokinetics after administration of enteric coated tablets are often highly
variable and this has been ascribed to the interaction of the dosage form with the physiology …

Simulation of gastrointestinal conditions is essential to adequately predict the in vivo
behavior of drug formulations. To reduce the size and number of human studies required to …

In vitro–in vivo correlation (IVIVC) allows prediction of the in vivo performance of a
pharmaceutical product based on its in vitro drug release profiles and can be used to …

The application of in silico modeling to predict the in vivo outcome of an oral drug product is
gaining a lot of interest. Fully relying on these models as a surrogate tool requires …

Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …