PDE4 inhibition is effective at resolving neutrophilic inflammation after LPS-challenge by
promoting caspase-3-dependent apoptosis of inflammatory cells in the pleural cavity. PDE4 …

PD-L1 is a ligand for PD-1, and its expression has been shown to be upregulated in
neutrophils harvested from septic patients. However, the effect of PD-L1 on neutrophil …

Inflammation is a response of the body to external stimuli (eg. chemical irritants, bacteria,
viruses, etc.), and when the stimuli are persistent, they tend to trigger chronic inflammation …

Background Delayed neutrophil apoptosis during sepsis may impact neutrophil organ
accumulation and tissue immune homeostasis. Elucidating the mechanisms underlying …

Inflammatory cell recruitment, activation, and apoptosis are highly regulated processes
involving several checkpoints controlling the resolution of inflammation. We investigated the …

Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell
function. The regulation of cAMP within leukocytes critically depends on its degradation by …

Neutrophils play a central role in host defense and are recruited in vast numbers to sites of
infection where they phagocytose and kill invading bacterial pathogens. Neutrophils have a …

Apoptosis of granulocytes and the subsequent clearance of apoptotic cells are important
processes for the successful resolution of inflammation. Signalling pathways, including …

The kinetic participation of macrophages is critical for inflammatory resolution and recovery
from myocardial infarction (MI), particularly with respect to the transition from the M1 to the …

Failure of acute inflammation to resolve leads to persistence of the inflammatory response
and may contribute to the development of chronic inflammation. Thus, an understanding of …