Recent developments in stem cell biology have enabled the study of cell fate decisions in
early human development that are impossible to study in vivo. However, understanding how …

Background Human pluripotent stem cells offer the best available model to study the
underlying cellular and molecular mechanisms of human embryonic lineage specification …

Single-cell profiling techniques create opportunities to delineate cell fate progression in
mammalian development. Recent studies have provided transcriptome data from human pre …

The derivation of human ES cells (hESCs) from human blastocysts represents one of the
milestones in stem cell biology. The full potential of hESCs in research and clinical …

Stem cells undergo cellular division during their differentiation to produce daughter cells
with a new cellular identity. However, the epigenetic events and molecular mechanisms …

During the transition from the inner cell mass (ICM) cells of blastocysts to pluripotent
embryonic stem cells (ESCs) in vitro, a normal developmental program is replaced in cells …

Pluripotent stem cells provide a powerful system to dissect the underlying molecular
dynamics that regulate cell fate changes during mammalian development. Here we report …

Embryonic stem (ES) cells can replicate indefinitely while retaining the capacity to
differentiate into functionally distinct cell types. ES cells proliferate and differentiate without …

The molecular mechanisms underlying pluripotency and lineage specification from
embryonic stem cells (ESCs) are largely unclear. Differentiation pathways may be …

The generation of induced pluripotent stem (iPS) cells presents a challenge to normal
developmental processes. The low efficiency and heterogeneity of most methods have …