A comparison of gene content and genome architecture of Trypanosoma brucei,
Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles …

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the
diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 …

To complement the sequencing of the three kinetoplastid genomes reported in this issue, we
have undertaken a whole-organism, proteomic analysis of the four life-cycle stages of …

The trypanosomatid protozoa Trypanosoma brucei, Trypanosoma cruzi and Leishmania
major are related human pathogens that cause markedly distinct diseases. Using …

African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-
Saharan Africa. We present the sequence and analysis of the 11 megabase-sized …

A decade of genome sequencing has transformed our understanding of how trypanosomatid
parasites have evolved and provided fresh impetus to explaining the origins of parasitism in …

Background Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans
and other wild and domestic mammals across Central and South America. It does not cause …

Many evolutionarily distant pathogenic organisms have evolved similar survival strategies to
evade the immune responses of their hosts. These include antigenic variation, through …

A total of 518 expressed sequence tags (ESTs) have been generated from clones randomly
selected from a cDNA library and a spliced leader sub-library of a Trypanosoma brucei …

Leishmania species cause a spectrum of human diseases in tropical and subtropical
regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase …