In autoimmune arthritis, traditionally classified as a T helper (Th) type 1 disease, the
activation of T cells results in bone destruction mediated by osteoclasts, but how T cells …

The mechanism whereby IL-17 drives rheumatoid arthritis remains incompletely understood.
We demonstrate that anti–IL-17 therapy in collagen-induced arthritis ameliorates bone …

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint
conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines …

Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation
and synovial hyperplasia in the joints that ultimately lead to cartilage and bone destruction …

Rheumatoid arthritis (RA) is an immune-mediated disease of the joints that is characterized
by chronic inflammation and synovial hyperplasia that eventually lead to cartilage and bone …

Studies on the immune regulation of osteoclasts in rheumatoid arthritis have promoted the
new research field of'osteoimmunology', which investigates the interplay between the …

Aberrant helper T cell activation has been implicated in the pathogenesis of an array of
autoimmune diseases. In this review, we summarize evidence that suggests the involvement …

This study determined the effect of type 17 helper T-cell (Th17) cytokines on
osteoclastogenesis in rheumatoid arthritis (RA). The expression of IL-17 and receptor …

Abstract T helper 17 (Th17) cells are important mediators of immune responses against
extracellular bacteria and fungi, and as such play critical regulatory roles in maintaining …

Objective Interleukin‐1 receptor antagonist–deficient (IL‐1Ra−/−) mice spontaneously
develop an inflammatory and destructive arthritis due to unopposed excess IL‐1 signaling …