Cardiac cell sheet transplantation improves damaged heart function via superior cell survival in comparison with dissociated cell injection

H Sekine, T Shimizu, I Dobashi, K Matsuura… - … Engineering Part A, 2011 - liebertpub.com
Regenerative therapies have currently emerged as one of the most promising treatments for
repair of the damaged heart. Recently, numerous researchers reported that isolated cell …

Cell sheet-based myocardial tissue engineering: new hope for damaged heart rescue

T Shimizu, H Sekine, M Yamato… - Current pharmaceutical …, 2009 - ingentaconnect.com
Regenerative therapy has currently emerged as one of the most promising treatments for the
patients suffering from severe heart failure. Several cell therapies by direct injection have …

Cell sheet transplantation for heart tissue repair

K Matsuura, Y Haraguchi, T Shimizu… - Journal of Controlled …, 2013 - Elsevier
Cell transplantation is attracting considerable attention as the next-generation therapy for
treatment of cardiovascular diseases. We have developed cell sheet engineering as a type …

Cell sheet engineering for heart tissue repair

S Masuda, T Shimizu, M Yamato, T Okano - Advanced drug delivery …, 2008 - Elsevier
Recently, myocardial tissue engineering has emerged as one of the most promising
therapies for patients suffering from severe heart failure. Nevertheless, conventional …

Fibroblast sheets co-cultured with endothelial progenitor cells improve cardiac function of infarcted hearts

H Kobayashi, T Shimizu, M Yamato, K Tono… - Journal of Artificial …, 2008 - Springer
We have already confirmed that cell sheet transplantation can improve damaged heart
function via continuous cytokine secretion. In this study, we hypothesized that cytokine …

Long-term survival and growth of pulsatile myocardial tissue grafts engineered by the layering of cardiomyocyte sheets

T Shimizu, H Sekine, Y Isoi, M Yamato, A Kikuchi… - Tissue …, 2006 - liebertpub.com
Recently researchers have attempted to bioengineer three-dimensional (3-D) myocardial
tissues using cultured cells in order to repair damaged hearts. In contrast to the conventional …

Three-dimensional cardiac tissue fabrication based on cell sheet technology

S Masuda, T Shimizu - Advanced drug delivery reviews, 2016 - Elsevier
Cardiac tissue engineering is a promising therapeutic strategy for severe heart failure.
However, conventional tissue engineering methods by seeding cells into biodegradable …

Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction

R Guo, M Morimatsu, T Feng, F Lan, D Chang… - Stem Cell Research & …, 2020 - Springer
Stem cell-derived sheet engineering has been developed as the next-generation treatment
for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem …

Endothelial cell coculture within tissue-engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts

H Sekine, T Shimizu, K Hobo, S Sekiya, J Yang… - Circulation, 2008 - Am Heart Assoc
Background—Regenerative therapies, including myocardial tissue engineering, have been
pursued as a new possibility to repair the damaged myocardium, and previously the …

Cell sheet engineering for myocardial tissue reconstruction

T Shimizu, M Yamato, A Kikuchi, T Okano - Biomaterials, 2003 - Elsevier
Myocardial tissue engineering has now emerged as one of the most promising treatments
for the patients suffering from severe heart failure. Tissue engineering has currently been …