BACKGROUND: Activation of NF-κB-dependent antiapoptotic genes may factor in the
chemoresistance of pancreatic cancer. It is not known whether NF-κB subunit composition …

We have demonstrated that nuclear factor-κB (NF-κB) is constitutively activated in human
pancreatic adenocarcinoma and human pancreatic cancer cell lines but not in normal …

The nuclear factor-kappaB (NF-κB) family of transcription factors are involved in multiple
cellular processes, including cytokine gene expression, cellular adhesion, cell cycle …

Background. Chemoresistance may involve the anti-apoptotic transcriptional regulator,
nuclear factor-κB (NF-κB). The purpose of this study was to determine whether …

Purpose: We seek to elucidate the role of constitutive nuclear factor κB (NFκB) activity in
human pancreatic cancer cells. We have demonstrated that the transcription factor NFκB is …

We previously reported that NF-κB is constitutively activated in most human pancreatic
cancer tissues and cell lines but not in normal pancreatic tissues and immortalized …

Background When activated, the nuclear factor (NF)-κB pathway is a potent cellular signal
that inhibits apoptotic cell death. Pancreatic cancer is resistant to the apoptotic effect of …

Constitutive classical NF-κB activation has been implicated in the development of pancreatic
cancer, and inhibition of classical NF-κB signaling sensitizes pancreatic cancer cells to …

Background. Nuclear factor-kappa B (NF-κB) is a known survival pathway, and it may
explain differential sensitivity to tumor necrosis factor-alpha (TNF-α) and chemotherapeutic …

Although the genetic profile of pancreatic cancer is emerging as a result of much research,
the role of specific genetic alterations that initiate tumorigenesis and produce its cardinal …