Circulating platelets contain high concentrations of TGF-β1 in their α-granules and release it
on platelet adhesion/activation. We hypothesized that uncontrolled in vitro release of platelet …

Platelets are a major source of transforming growth factor‐β1 (TGF‐β1) in the circulation as
they release latent growth factor in response to activation. We report here that human …

Transforming growth factor-β1 (TGF-β1) has potent physiologic and pathologic effects on a
variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much …

When treating diseases related primarily to tissue remodeling and fibrosis, it is desirable to
regulate TGFβ concentration and modulate its biological effects. The highest cellular …

We have studied the effect of transforming growth factor β1 (TGF‐β1) on vascular smooth
muscle cell (SMC) mitogenesis and expression of thrombospondin and other growth related …

The cytokine transforming growth factor-β (TGF-β) was initially purified from human platelets,
a rich source of this protein. In addition to platelets, TGF-β1 is also found in other blood …

Objective—Aortic valve stenosis (AS) is characterized by fibrosis and calcification of valves
leading to aortic valve narrowing, resulting in high wall shear stress across the valves. We …

Control of the thickness of the arterial wall is critical, as excessive overgrowth of constituent
smooth muscle cells (SMCs) may interfere with blood flow. Effects on SMCs in vitro of …

Genetic studies in animals and humans indicate that gene mutations that functionally perturb
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …

The cardiac pathological response to sustained pressure overload involves myocyte
hypertrophy and dysfunction along with interstitial changes such as fibrosis and reduced …