Hypertension is a key risk factor for cardiovascular disease, and new treatments are needed.
Uric acid reduction lowers blood pressure (BP) in adolescents, suggesting a direct …

Allopurinol lowers blood pressure in adolescents and has other vasoprotective effects.
Whether similar benefits occur in older individuals remains unclear. We hypothesized that …

Objective To determine whether serum urate reduction with allopurinol lowers blood
pressure (BP) in young adults and the mechanisms mediating this hypothesized effect …

J Clin Hypertens (Greenwich). 2013; 15: 435–442© 2012 Wiley Periodicals, Inc. Allopurinol
is a potent xanthine oxidase inhibitor that is used in hyperuricemic patients to prevent gout. It …

Background Gout gives rise to increased risk of cardiovascular events. Gout attacks can be
effectively prevented with urate lowering drugs, and allopurinol potentially reduces …

Background: The purpose of this meta-analysis was to determine if uric acid-lowering
therapy is associated with a decrease in blood pressure (BP) and serum creatinine levels …

Context Hyperuricemia is a predictor for the development of hypertension and is commonly
present in new-onset essential hypertension. Experimentally increasing uric acid levels …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Guidelines recommend that the
therapeutic goal of urate‐lowering therapy (ULT) is to achieve a urate concentration of≤ 6 …

Background Asymptomatic hyperuricemia increases renal and cardiovascular (CV) risk. We
previously conducted a 2-year, single-blind, randomized, controlled trial of allopurinol …

Effect of Allopurinol in Chronic Kidney Disease Progression... : Clinical Journal of the
American Society of Nephrology Effect of Allopurinol in Chronic Kidney Disease …