Identification of a cross-talk between EGFR and Wnt/beta-catenin signaling pathways in HepG2 liver cancer cells
EGFRis a transmembrane receptor tyrosine kinase involved in regulating cell proliferation,
differentiation and survival. EGFR is actively pursued as a therapeutic target because its …
differentiation and survival. EGFR is actively pursued as a therapeutic target because its …
EGF-induced ERK activation promotes CK2-mediated disassociation of α-catenin from β-catenin and transactivation of β-catenin
H Ji, J Wang, H Nika, D Hawke, S Keezer, Q Ge… - Molecular cell, 2009 - cell.com
Increased transcriptional activity of β-catenin resulting from Wnt/Wingless-dependent or-
independent signaling has been detected in many types of human cancer, but the …
independent signaling has been detected in many types of human cancer, but the …
Mechanism of β-catenin-mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 3 β-inactivated prostate …
KKN Guturi, T Mandal, A Chatterjee, M Sarkar… - Journal of Biological …, 2012 - ASBMB
Wnt/β-catenin and EGFR pathways are important in cancer development and often
aberrantly activated in human cancer. However, it is very important to understand the …
aberrantly activated in human cancer. However, it is very important to understand the …
Knockdown of EGFR inhibits growth and invasion of gastric cancer cells
Y Zhen, L Guanghui, Z Xiefu - Cancer gene therapy, 2014 - nature.com
The epidermal growth factor receptor (EGFR) is an oncogenic trans-membranous receptor,
which is overexpressed in multiple human cancers. However, the role of EGFR in gastric …
which is overexpressed in multiple human cancers. However, the role of EGFR in gastric …
Convergence between Wnt-β-catenin and EGFR signaling in cancer
T Hu, C Li - Molecular cancer, 2010 - Springer
Wnt and EGFR signaling play key roles in embryonic development and cell proliferation. It is
well documented that dysregulation of these two pathways often leads to tumorigenesis with …
well documented that dysregulation of these two pathways often leads to tumorigenesis with …
EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma
EGFRvIII is a tumor-specific variant of the epidermal growth factor receptor (EGFR). Although
EGFRvIII is most commonly found in glioblastoma, its expression in other tumor types …
EGFRvIII is most commonly found in glioblastoma, its expression in other tumor types …
[HTML][HTML] bFGF-mediated phosphorylation of δ-catenin increases its protein stability and the ability to induce the nuclear redistribution of β-catenin
G Chen, N An, Y Zhu, R Zhou, MG Noh… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Recently, we have shown that δ-catenin strengthened the epidermal growth factor receptor
(EGFR)/Erk1/2 signaling pathway through the association between EGFR and δ-catenin …
(EGFR)/Erk1/2 signaling pathway through the association between EGFR and δ-catenin …
A novel EGFR isoform confers increased invasiveness to cancer cells
M Zhou, H Wang, K Zhou, X Luo, X Pan, B Shi, H Jiang… - Cancer research, 2013 - AACR
As a validated therapeutic target in several human cancers, the EGF receptor (EGFR)
provides a focus to gain deeper insights into cancer pathophysiology. In this study, we report …
provides a focus to gain deeper insights into cancer pathophysiology. In this study, we report …
Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations
W Han, HW Lo - Cancer letters, 2012 - Elsevier
The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated
molecular pathways in human cancers. Despite its well-established importance in tumor …
molecular pathways in human cancers. Despite its well-established importance in tumor …