In 1976, Juliano and Ling 1 reported expression of a 170 kDa protein in colchicine‐resistant
Chinese hamster ovary (CHO) cells that was absent in drug‐sensitive cells. Because this …

One of the many obstacles to effective drug treatment is the efflux transporter P-glycoprotein
(P-gp), which can restrict the plasma and intracellular concentrations of numerous …

The product of the ABCB1 gene, P-glycoprotein (PGP), is a transmembrane active efflux
pump for a variety of drugs. It is a putative mechanism of multidrug resistance in a range of …

The human ABCB1 (MDR1)-encoded multidrug transporter P-glycoprotein (P-gp) plays a
major role in disposition and efficacy of a broad range of drugs including anticancer agents …

ATP-binding cassette transporter P-glycoprotein (ABCB1) is responsible for the multidrug
resistance (MDR1) phenotype observed in cancer cells. SJG-136, a new …

Simple Summary Overexpression of ABCB1 has been identified in a wide range of multidrug-
resistant cancers. ABCB1 can become upregulated in many ways, and understanding these …

Introduction: The human multidrug resistance gene ATP-binding cassette B1 (ABCB1) codes
for P-glycoprotein (P-gp), an important membrane-bound efflux transporter known to confer …

The development of drug resistance continues to be a dominant hindrance toward curative
cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and …

Expression of the ABC transporter P‐glycoprotein (P‐gp or ABCB1) is associated with
resistance to chemotherapy in cancer. However, early investigations into the regulation of …

Abstract P-glycoprotein (ABCB1, MDR1) belongs to the ABC transporter family transporting
a wide range of drugs and xenobiotics from intra-to extracellular at many biological …