Rooted in the mechanism of action of antibiotics and subject to bacterial evolution, antibiotic
resistance is difficult and perhaps impossible to overcome. Nevertheless, strategies can be …

Antibiotic resistance is one of the greatest current threats to human health, and without
significant action we face the chilling prospect of a world without effective antibiotics …

The discovery of penicillin by Alexander Fleming in 1928 changed the course of medicine.
Since then, antibiotics have represented virtually the only effective treatment option for …

The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …

The growing number of bacterial pathogens that are resistant to numerous antibiotics is a
cause for concern around the globe. There have been no new broad‐spectrum antibiotics …

The rise of multi-drug resistant (MDR) pathogens poses a significant challenge to the field of
infectious disease treatment. To overcome this problem, novel strategies are being explored …

Resistance to available antibiotics in pathogenic bacteria is currently a global challenge
since the number of strains that are resistant to multiple types of antibiotics has increased …

Antibiotic resistance in Gram-negative pathogens has emerged and constituted a global
crisis, thereby novel antibiotics and other anti-infective strategies are urgently needed …

Antibiotics have always been considered as one of the most relevant discoveries of the
twentieth century. Unfortunately, the dawn of the antibiotic era has sadly corresponded to the …

Multiple approaches have been developed to combat bacterial resistance. However, the
combination of antibiotic resistance mechanisms by bacteria and the limited number of …