Chronic inflammation constitutes an important link between obesity and its
pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a …

Several lines of preclinical and clinical research have confirmed that chronic low-grade
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …

Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …

The worldwide obesity epidemic has become a major health concern, because it contributes
to higher mortality due to an increased risk for noncommunicable diseases including …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Weight gain and obesity are major risk factors for conditions and diseases ranging from
insulin resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of …

Chronic inflammation is a characteristic of obesity and is associated with accompanying
insulin resistance, a hallmark of type 2 diabetes mellitus (T2DM). Although proinflammatory …

Obesity is a worldwide epidemic that continues to grow at an alarming rate. This condition
increases the morbidity and mortality associated with both acute and chronic diseases …

Obesity may be viewed as a chronic low-grade inflammatory disease as well as a metabolic
disease. Indeed, unbalanced production of pro-and anti-inflammatory adipocytokines …

This review summarizes the role of macrophages in adipose tissue remodeling, particularly
focusing on the paracrine loop between adipocytes and macrophages. The adipose tissue …