Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype

A Marçais, L Lhermitte, M Artesi, C Laurent, K Durkin… - Leukemia, 2021 - nature.com
Adult T-cell leukemia/lymphoma (ATL) carries a poor prognosis even in indolent subtypes.
We performed targeted deep sequencing combined with mapping of HTLV-1 proviral …

Evolution of retrovirus-infected premalignant T-cell clones prior to adult T-cell leukemia/lymphoma diagnosis

AG Rowan, R Dillon, A Witkover… - Blood, The Journal …, 2020 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy caused
by human T-cell leukemia virus type-1 (HTLV-1). ATL is preceded by decades of chronic …

The genomic landscape of adult T cell leukemia/lymphoma

C Vicente, J Cools - Nature genetics, 2015 - nature.com
Adult T cell leukemia/lymphoma (ATL) is a neoplasm linked to human T-lymphotropic virus
type-1 (HTLV-1) infection and is refractory to current combination chemotherapy. A large …

Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma

K Kataoka, M Iwanaga, J Yasunaga… - Blood, The Journal …, 2018 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is a heterogeneous group of peripheral T-cell
malignancies characterized by human T-cell leukemia virus type-1 infection, whose genetic …

Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma

M Yamagishi, M Kubokawa, Y Kuze, A Suzuki… - Nature …, 2021 - nature.com
Subclonal genetic heterogeneity and their diverse gene expression impose serious
problems in understanding the behavior of cancers and contemplating therapeutic …

Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality

M Artesi, A Marçais, K Durkin, N Rosewick, V Hahaut… - Leukemia, 2017 - nature.com
Adult T-cell leukemia (ATL) is an aggressive CD4+ T-cell malignancy caused by the
oncogenic retrovirus human T-cell leukemia virus-1 (HTLV-1). 1 Although the cumulative …

Whole-genome landscape of adult T-cell leukemia/lymphoma

Y Kogure, T Kameda, J Koya… - Blood, The Journal …, 2022 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is an aggressive neoplasm immunophenotypically
resembling regulatory T cells, associated with human T-cell leukemia virus type-1. Here, we …

Genetic profile of adult T‐cell leukemia/lymphoma in Okinawa: Association with prognosis, ethnicity, and HTLV‐1 strains

S Sakihama, K Morichika, R Saito, M Miyara… - Cancer …, 2021 - Wiley Online Library
Genetic alterations in adult T‐cell leukemia/lymphoma (ATLL), a T‐cell malignancy
associated with HTLV‐1, and their clinical impacts, especially from the perspective of viral …

Integrated molecular analysis of adult T cell leukemia/lymphoma

K Kataoka, Y Nagata, A Kitanaka, Y Shiraishi… - Nature …, 2015 - nature.com
Adult T cell leukemia/lymphoma (ATL) is a peripheral T cell neoplasm of largely unknown
genetic basis, associated with human T cell leukemia virus type-1 (HTLV-1) infection. Here …

Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma

A Oshiro, H Tagawa, K Ohshima, K Karube, N Uike… - Blood, 2006 - ashpublications.org
Aggressive adult T-cell leukemia/lymphoma (ATLL) such as acute and lymphoma types are
fatal diseases with poor prognosis. Although these 2 subtypes feature different …