The evolutionary conserved protein Cdc48/VCP is involved in various cellular processes,
such as protein degradation, membrane fusion and chaperone activity. Increased levels of …

Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory
functions in a broad array of cellular processes. Working with various cofactors, Cdc48 …

Abstract The AAA-ATPase Cdc48 (also called p97 or VCP) acts as a key regulator in
proteolytic pathways, coordinating recruitment and targeting of substrate proteins to the 26S …

Mutation in CDC48 (cdc48 S565G), a gene essential in the endo-plasmic reticulum (ER)-
associated protein degradation (ERAD) pathway, led to the discovery of apoptosis as a …

The cellular level of the CDC25A phosphatase is tightly regulated during both the normal
and genotoxic-perturbed cell cycle. Here, we describe a caspase-dependent cleavage of …

We show that Cdc6, an essential initiation factor for DNA replication, undergoes caspase-3–
mediated cleavage in the early stages of apoptosis in HeLa cells and SK-HEP-1 cells …

Cdc48 is an essential, highly prominent ATP driven machine in eukaryotic cells.
Physiological function of Cdc48 has been found in a multitude of cellular processes, for …

The accumulation of misfolded proteins is associated with multiple neurodegenerative
disorders, but it remains poorly defined how this accumulation causes cytotoxicity. Here, we …

Cdc20 is an essential cell-cycle regulator required for the completion of mitosis in organisms
from yeast to man and contains at its C terminus a WD40 repeat domain that mediates …

Cdc48p/p97 is a highly conserved essential AAA protein that is required for many cellular
processes, and is identified as a causative gene for an autosomal dominant human disorder …