Burns have become an important public health problem in the last two decades, with just
over a quarter of a million deaths annually. Major burns are accompanied by a strong …

Burn are diverse and complex injuries that not only have local effects but also serious
systemic consequences through severe and prolonged inflammatory response. They are …

Survival of burn patients is contingent on effective wound healing, a complex process that
requires coordinated responses of myeloid cells and inflammatory pathways. NLRP3, which …

Although sepsis in burn patients is a major contributor to mortality, treatments are not always
effective and underlying mechanisms have yet to be completely elucidated. NLRP3 …

Inflammation is a pivotal defense system of body. Unfortunately, when homeostasis falters,
the same inflammatory mechanism acts as a double-edged sword, and turns offensive …

Inflammasomes are cytosolic pattern recognition receptors that recognize pathogen-
associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) …

Severe burns trigger a wide range of responses in the victim. Initial vascular changes are
followed by hypermetabolic, inflammatory and immunologic changes. The prolonged …

Despite improvements in the management of burn injury1, 2 and the development of broad-
spectrum antibiotics, infections still remain a major cause of morbidity and mortality in burn …

Inflammasomes represent a group of protein complexes that contribute to host defense
against pathogens and repair processes upon the induction of inflammation. However …

Inflammation is an immune response to infectious agents and to signals that arise from host
molecules in stress situations or after tissue damage. Many innate immune receptors take …