Gene–environment interactions mediated at the epigenetic level may provide an initial step
in delivering an appropriate response to environmental changes. 5-Hydroxymethylcytosine …

Mounting evidence points to critical roles for DNA modifications, including 5-methylcytosine
(5mC) and its oxidized forms, in the development, plasticity and disorders of the mammalian …

DNA methylation dynamics influence brain function and are altered in neurological
disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base that is derived from 5 …

Environmental stress is among the most important contributors to increased susceptibility to
develop psychiatric disorders, including anxiety and post-traumatic stress disorder. While …

Hydroxymethylcytosine (5-hmC) is a novel environmentally sensitive DNA modification that
is highly enriched in post-mitotic neurons and is associated with active transcription of …

Background Epigenetic processes play a key role in orchestrating transcriptional regulation
during the development of the human central nervous system. We previously described …

Purpose: Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine
(5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten …

Because of the difficulty in collecting fresh brains of humans at different ages, it remains
unknown how epigenetic regulation occurs in the primate brains during aging. In the present …

Hydroxymethylcytosine (5-hmC) is a newly discovered modified form of cytosine that has
been suspected to be an important epigenetic modification in neurodevelopment. While …

Epigenetic modifications to cytosine have been shown to regulate transcription in cancer,
embryonic development, and recently neurodegeneration. While cytosine methylation …