Dysregulation of circulating miRNAs promotes the pathogenesis of diabetes-induced cardiomyopathy

U Ahmed, UA Ashfaq, M Qasim, I Ahmad, HU Ahmad… - PLoS …, 2021 - journals.plos.org
Diabetic Cardiomyopathy (DCM) is characterized by myocardial dysfunction caused by
diabetes mellitus. After-effects of diabetic cardiomyopathy are far more lethal than non …

Investigating microRNAs in diabetic cardiomyopathy as tools for early detection and therapeutics

P Mathur, V Rani - Molecular and Cellular Biochemistry, 2023 - Springer
To profile microRNAs population of glucose-induced cardiomyoblast cell line and identify
the differentially expressed microRNAs and their role under pre-diabetes and diabetes …

Pathogenesis of Diabetic Cardiomyopathy and role of miRNA

U Ahmed, S Khaliq, HU Ahmad, I Ahmad… - Critical Reviews™ in …, 2021 - dl.begellhouse.com
Diabetic cardiomyopathy is characterized as abnormal function and structure of myocardium
associated with diabetes irrespective of other cardiac risk factors like hypertension or …

MicroRNA targets and biomarker validation for diabetes-associated cardiac fibrosis

ZQ Jin - Pharmacological research, 2021 - Elsevier
Cardiac fibrosis is one of the main characteristics of diabetic cardiomyopathy and manifests
excessive accumulation of extracellular matrix proteins in the heart. Several signaling …

MicroRNAs: A critical regulator and a promising therapeutic and diagnostic molecule for diabetic cardiomyopathy

P Mathur, V Rani - Current Gene Therapy, 2021 - ingentaconnect.com
The risk of heart failure is 2-5 times higher in diabetic patients as compared to non-diabetic
patients with similar comorbidities. Recent reports suggest that nearly half of the diabetic …

Cardiac miRNA expression and their mRNA targets in a rat model of prediabetes

É Sághy, I Vörös, B Ágg, B Kiss, G Koncsos… - International Journal of …, 2020 - mdpi.com
Little is known about the mechanism of prediabetes-induced cardiac dysfunction. Therefore,
we aimed to explore key molecular changes with transcriptomic and bioinformatics …

The role of microRNAs in the pathophysiology, diagnosis, and treatment of diabetic cardiomyopathy

M Abdel Rhman, P Owira - Journal of Pharmacy and …, 2022 - academic.oup.com
Introduction Diabetic cardiomyopathy (DCM) is an end-point macrovascular complication
associated with increased morbidity and mortality in 12% of diabetic patients. MicroRNAs …

Differentially expressed microRNAs and their target genes in the hearts of streptozotocin-induced diabetic mice

X Diao, E Shen, X Wang, B Hu - Molecular medicine …, 2011 - spandidos-publications.com
Persistent hyperglycemia in diabetic patients has been associated with cardiac hypertrophy,
myocardial fibrosis and cardiac dysfunction. However, the underlying mechanisms of this …

Recent highlights of research on miRNAs as early potential biomarkers for cardiovascular complications of type 2 diabetes mellitus

A Bielska, M Niemira, A Kretowski - International Journal of Molecular …, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) and its complications pose a serious threat to the life and
health of patients around the world. The most dangerous complications of this disease are …

Serum miRNA profile in diabetic patients with ischemic heart disease as a promising non-invasive biomarker

A Bielska, M Niemira, W Bauer, I Sidorkiewicz… - Frontiers in …, 2022 - frontiersin.org
The increasing morbidity and mortality of type 2 diabetic mellitus (T2DM) patients with
ischemic heart disease (IHD) highlight an urgent need to identify early biomarkers, which …