Objective To clarify the impact of digoxin on death and clinical outcomes across all
observational and randomised controlled trials, accounting for study designs and methods …

Abstract Aims The Digitalis Investigation Group (DIG) trial, the only large randomized trial of
digoxin in heart failure, reported a neutral effect on mortality and a significant reduction in …

Aims In the Digitalis Investigation Group (DIG) trial, digoxin reduced mortality or
hospitalization due to heart failure (HF) in several pre‐specified high‐risk subgroups of HF …

Aims To determine the effects of digoxin on all-cause mortality and heart failure (HF)
hospitalizations, regardless of ejection fraction, accounting for serum digoxin concentration …

There are conflicting data regarding the effect of digoxin use on mortality in patients with
atrial fibrillation (AF) or with congestive heart failure (CHF). The aim of this meta-analysis …

Background The role of cardiac glycosides in treating patients with chronic heart failure and
normal sinus rhythm remains controversial. We studied the effect of digoxin on mortality and …

Digitalis is the oldest compound in cardiovascular medicine that continues to be used in
contemporary clinical practice. 1 Evidence supporting the beneficial effects of digoxin on …

BACKGROUND: In heart failure (HF), digoxin at low serum digoxin concentrations (SDC)
reduces all-cause mortality and HF hospitalizations. However, the effects of digoxin on other …

Background—About half of the 5 million heart failure patients in the United States have
diastolic heart failure (clinical heart failure with normal or near-normal ejection fraction) …

In 2015, 3 independent meta-analyses raised concerns about digoxin therapy being
associated with an increased mortality risk in patients with atrial fibrillation (AF) and with …